Follow your heart and trust your gut: Co-development of heart and gut tissue in organoids

Mingxia Gu¹, Aaron M Zorn²

Affiliations

¹ Center for Stem Cell and Organoid Medicine (CuSTOM), Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA; Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA. Electronic address: mingxia.gu@cchmc.org.
² Center for Stem Cell and Organoid Medicine (CuSTOM), Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA. Electronic address: aaron.zorn@cchmc.org.

PMID: 34861142
DOI: 10.1016/j.stem.2021.09.003

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Follow your heart and trust your gut: Co-development of heart and gut tissue in organoids

Mingxia Gu et al. Cell Stem Cell. 2021.

Free article

. 2021 Dec 2;28(12):2037-2038.

doi: 10.1016/j.stem.2021.09.003.

Authors

Mingxia Gu¹, Aaron M Zorn²

Affiliations

¹ Center for Stem Cell and Organoid Medicine (CuSTOM), Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA; Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA. Electronic address: mingxia.gu@cchmc.org.
² Center for Stem Cell and Organoid Medicine (CuSTOM), Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA. Electronic address: aaron.zorn@cchmc.org.

PMID: 34861142
DOI: 10.1016/j.stem.2021.09.003

Abstract

Organogenesis is orchestrated by the interaction of different embryonic tissues. Recent reports in Cell Stem Cell (Silva et al., 2021; Rossi et al., 2021) and Nature Biotechnology (Drakhlis et al., 2021) recapitulate the co-development of embryonic mesoderm and endoderm in PSCs to promote formation of complex heart and gut organoids.

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Capturing Cardiogenesis in Gastruloids.
Rossi G, Broguiere N, Miyamoto M, Boni A, Guiet R, Girgin M, Kelly RG, Kwon C, Lutolf MP. Rossi G, et al. Cell Stem Cell. 2021 Feb 4;28(2):230-240.e6. doi: 10.1016/j.stem.2020.10.013. Epub 2020 Nov 10. Cell Stem Cell. 2021. PMID: 33176168 Free PMC article.
Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids.
Silva AC, Matthys OB, Joy DA, Kauss MA, Natarajan V, Lai MH, Turaga D, Blair AP, Alexanian M, Bruneau BG, McDevitt TC. Silva AC, et al. Cell Stem Cell. 2021 Dec 2;28(12):2137-2152.e6. doi: 10.1016/j.stem.2021.11.007. Cell Stem Cell. 2021. PMID: 34861147

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Follow your heart and trust your gut: Co-development of heart and gut tissue in organoids

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Follow your heart and trust your gut: Co-development of heart and gut tissue in organoids

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