Elimination of fluorescent protein immunogenicity permits modeling of metastasis in immune-competent settings

Affiliations

¹ Public Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: cgrzelak@fredhutch.org.
² Public Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
³ Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
⁴ Public Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, WA, USA.
⁵ Altius Institute for Biomedical Sciences, Seattle, WA, USA.
⁶ Public Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: cghajar@fredhutch.org.

Candice A Grzelak et al. Cancer Cell. 2022.

. 2022 Jan 10;40(1):1-2.

doi: 10.1016/j.ccell.2021.11.004. Epub 2021 Dec 2.

¹ Public Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: cgrzelak@fredhutch.org.
² Public Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
³ Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
⁴ Public Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, WA, USA.
⁵ Altius Institute for Biomedical Sciences, Seattle, WA, USA.
⁶ Public Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: cghajar@fredhutch.org.

No abstract available

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Recognition of observer effect is required for rigor and reproducibility of preclinical animal studies.
Day CP, Pérez-Guijarro E, Lopès A, Goldszmid RS, Murgai M, Wakefield L, Merlino G. Day CP, et al. Cancer Cell. 2022 Mar 14;40(3):231-232. doi: 10.1016/j.ccell.2022.01.015. Epub 2022 Feb 17. Cancer Cell. 2022. PMID: 35180384 No abstract available.
Overcoming unintended immunogenicity in immunocompetent mouse models of metastasis: the case of GFP.
Schultheiß C, Binder M. Schultheiß C, et al. Signal Transduct Target Ther. 2022 Mar 3;7(1):68. doi: 10.1038/s41392-022-00929-9. Signal Transduct Target Ther. 2022. PMID: 35241648 Free PMC article. No abstract available.

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