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Comment
. 2021 Dec 2;81(23):4763-4765.
doi: 10.1016/j.molcel.2021.11.013.

Signaling is silver, silence is golden: RHBDL2 intramembrane proteolysis prevents stochastic Ca2+ signaling in unstimulated cells

Matthias Koch  1 , Lucía Chávez-Gutiérrez  2
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Signaling is silver, silence is golden: RHBDL2 intramembrane proteolysis prevents stochastic Ca2+ signaling in unstimulated cells

Matthias Koch et al. Mol Cell. .
Free article

Abstract

In this issue of Molecular Cell, Grieve et al. (2021) reveal Orai1/CRAC channels as atypical substrates of the RHBDL2 rhomboid and unveil the selective processing of stochastically activated CRAC channels by RHBLD2 as the "conformational surveillance" mechanism that prevents unwanted CRAC signaling in unstimulated cells.

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