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. 2022 Apr 1;42(4):738-743.
doi: 10.1097/IAE.0000000000003374.

ENDOTHELIN-1 AS A RISK FACTOR IN RETINAL VEIN OCCLUSION

Wolfgang List  1 , Martin Weger  1 , Silke Pinter-Hausberger  1 , Florian Posch  2 , Jasmin Rabensteiner  3 , Sabine Pailer  3 , Andreas Wedrich  1 , Laura Posch-Pertl  1
Affiliations

ENDOTHELIN-1 AS A RISK FACTOR IN RETINAL VEIN OCCLUSION

Wolfgang List et al. Retina. .

Abstract

Purpose: Retinal vein occlusion (RVO) risk factors largely coincide with cardiovascular risk factors. Endothelin-1 (ET-1), the most potent vasoconstrictor with proinflammatory properties, is a known cardiovascular risk factor. In this study, we explore the role of serum ET-1 as a potential risk factor for RVO.

Methods: Endothelin-1 serum levels were measured in patients with RVO and control subjects. Samples were measured using the sandwich enzyme-linked immunosorbent assay for the quantitative determination of human big endothelin-1 (Biomedica Group, Austria).

Results: The study consisted of 147 RVO patients and 150 control subjects. Median serum ET-1 was significantly higher in RVO patients (0.26 pmol/L; range, 0.19-0.37 pmol/L) compared with control subjects (0.10 pmol/L; range, 0.05-0.22 pmol/L) (P < 0.0001) independent of the occlusion site. The difference remained significant after adjusting for arterial hypertension, diabetes mellitus, history of stroke, history of myocardial infarction, history of venous thromboembolism, glomerular filtration rate, and c-reactive protein.

Conclusion: In conclusion, our results suggest that ET-1 is a potential risk factor for all types of RVO.

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References

    1. Song P, Xu Y, Zha M, et al. Global epidemiology of retinal vein occlusion: a systematic review and meta-analysis of prevalence, incidence, and risk factors. J Glob Health 2019;9:010427.
    1. O'Mahoney PR, Wong DT, Ray JG. Retinal vein occlusion and traditional risk factors for atherosclerosis. Arch Ophthalmol 2008;126:692–699.
    1. Kowalczyk A, Kleniewska P, Kolodziejczyk M, et al. The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis. Arch Immunol Ther Exp (Warsz) 2015;63:41–52.
    1. Davenport AP, Hyndman KA, Dhaun N, et al. Endothelin. Pharmacol Rev 2016;68:357–418.
    1. Antonopoulos A, Kyriacou C, Kazianis G. Significance of endothelin-1 in myocardial infarction. Hellenic J Cardiol 2007;48:161–164.