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. 2022 Jan;38(1):11-14.
doi: 10.1016/j.pt.2021.10.005. Epub 2021 Dec 1.

Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era

James A Watson  1 , Nicholas J White  1 , Arjen M Dondorp  2
Affiliations

Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era

James A Watson et al. Trends Parasitol. 2022 Jan.

Abstract

Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high Plasmodium falciparum transmission in sub-Saharan Africa. From this we estimate that the malaria-attributable childhood mortality in the pretreatment era was between 15% and 24%.

Keywords: falciparum malaria; hemoglobin S; malaria-attributable mortality; sickle cell.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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