Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine

Yunlong Cao^#^{1

2

3}, Xiaohua Hao^#⁴, Xi Wang^#^{4

5}, Qianhui Wu^#⁶, Rui Song⁴, Dong Zhao⁴, Weiliang Song^{7

8}, Yao Wang^{9

7}, Ayijiang Yisimayi^{7

8}, Wei Wang⁶, Wen Zhang⁴, Juan Du^{4

5}, Hongjie Yu^{10

11

12}, Xiaoliang Sunney Xie^{13

14

15

16}, Ronghua Jin^{17

18

19}

Affiliations

¹ Changping Laboratory, Beijing, China. yunlongcao@pku.edu.cn.
² Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China. yunlongcao@pku.edu.cn.
³ Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China. yunlongcao@pku.edu.cn.
⁴ National Center For Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
⁵ Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
⁶ School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
⁷ Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China.
⁸ School of Life Sciences, Peking University, Beijing, China.
⁹ Changping Laboratory, Beijing, China.
¹⁰ School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China. yhj@fudan.edu.cn.
¹¹ Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China. yhj@fudan.edu.cn.
¹² Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China. yhj@fudan.edu.cn.
¹³ Changping Laboratory, Beijing, China. sunneyxie@biopic.pku.edu.cn.
¹⁴ Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China. sunneyxie@biopic.pku.edu.cn.
¹⁵ Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China. sunneyxie@biopic.pku.edu.cn.
¹⁶ School of Life Sciences, Peking University, Beijing, China. sunneyxie@biopic.pku.edu.cn.
¹⁷ Changping Laboratory, Beijing, China. ronghuajin@ccmu.edu.cn.
¹⁸ National Center For Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. ronghuajin@ccmu.edu.cn.
¹⁹ Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. ronghuajin@ccmu.edu.cn.

^# Contributed equally.

PMID: 34862467
PMCID: PMC8640508
DOI: 10.1038/s41422-021-00596-5

Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine

Yunlong Cao et al. Cell Res. 2022 Jan.

. 2022 Jan;32(1):107-109.

doi: 10.1038/s41422-021-00596-5. Epub 2021 Dec 3.

Authors

Affiliations

¹ Changping Laboratory, Beijing, China. yunlongcao@pku.edu.cn.
² Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China. yunlongcao@pku.edu.cn.
³ Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China. yunlongcao@pku.edu.cn.
⁴ National Center For Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
⁵ Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
⁶ School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.
⁷ Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China.
⁸ School of Life Sciences, Peking University, Beijing, China.
⁹ Changping Laboratory, Beijing, China.
¹⁰ School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China. yhj@fudan.edu.cn.
¹¹ Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China. yhj@fudan.edu.cn.
¹² Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China. yhj@fudan.edu.cn.
¹³ Changping Laboratory, Beijing, China. sunneyxie@biopic.pku.edu.cn.
¹⁴ Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, China. sunneyxie@biopic.pku.edu.cn.
¹⁵ Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China. sunneyxie@biopic.pku.edu.cn.
¹⁶ School of Life Sciences, Peking University, Beijing, China. sunneyxie@biopic.pku.edu.cn.
¹⁷ Changping Laboratory, Beijing, China. ronghuajin@ccmu.edu.cn.
¹⁸ National Center For Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. ronghuajin@ccmu.edu.cn.
¹⁹ Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. ronghuajin@ccmu.edu.cn.

^# Contributed equally.

PMID: 34862467
PMCID: PMC8640508
DOI: 10.1038/s41422-021-00596-5

No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1. Humoral immune responses against prototype and variants of SARS-CoV-2 among participants.**
Results of authentic virus neutralization assays using participants’ plasma against SARS-CoV-2 prototype strain (a), Beta strain (b), Gamma strain (c), and Delta strain (d). The geometric mean titer (GMT), geometric standard deviation, and pairwise fold-changes of 50% neutralization titers are labeled. HCS, human convalescent serum. Booster doses were administrated on Day 0. Statistical significances were analyzed by two-sided paired t-tests with log-transformation.

See this image and copyright information in PMC

References

1. https://ourworldindata.org/covid-vaccinations Accessed October 16, 2021 (2021).
1. Abu-Raddad LJ, et al. N. Engl. J. Med. 2021;385:187–189. doi: 10.1056/NEJMc2104974. - DOI - PMC - PubMed
1. Bar-On YM, et al. N. Engl. J. Med. 2021;385:1393–1400. doi: 10.1056/NEJMoa2114255. - DOI - PMC - PubMed
1. Vogel G, et al. Science. 2021;372:1138–1138. doi: 10.1126/science.372.6547.1138. - DOI - PubMed
1. Cao Y, et al. Cell Res. 2021;31:732–741. doi: 10.1038/s41422-021-00514-9. - DOI - PMC - PubMed

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Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine

Affiliations

Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine

Authors

Affiliations

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical