Anti-histamines boost immunotherapy

Comment

Megan Cully. Nat Rev Drug Discov. 2022 Jan.

. 2022 Jan;21(1):17.

doi: 10.1038/d41573-021-00204-6.

No abstract available

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The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1.
Li H, Xiao Y, Li Q, Yao J, Yuan X, Zhang Y, Yin X, Saito Y, Fan H, Li P, Kuo WL, Halpin A, Gibbons DL, Yagita H, Zhao Z, Pang D, Ren G, Yee C, Lee JJ, Yu D. Li H, et al. Cancer Cell. 2022 Jan 10;40(1):36-52.e9. doi: 10.1016/j.ccell.2021.11.002. Epub 2021 Nov 24. Cancer Cell. 2022. PMID: 34822775 Free PMC article.

1. Li, H. et al. The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer Cell https://doi.org/10.1016/j.ccell.2021.11.002 (2021)