Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Mar;75(3):757-759.
doi: 10.1002/hep.32269. Epub 2021 Dec 19.

Letter to the editor: Exacerbation of autoimmune hepatitis after COVID-19 vaccination

Zhujun Cao  1 , Honglian Gui  1 , Zike Sheng  1 , Haiguang Xin  1 , Qing Xie  1
Affiliations
Comment

Letter to the editor: Exacerbation of autoimmune hepatitis after COVID-19 vaccination

Zhujun Cao et al. Hepatology. 2022 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Nothing to report.

Figures

FIGURE 1
FIGURE 1
Histological findings and evolution of laboratory tests. At low‐magnification (×100), hematoxylin and eosin staining shows moderate to severe interface hepatitis with a dense lymphoid infiltrate (A), and Masson staining shows the formation of fibrous septa (B). At high magnification (×400) with hematoxylin and eosin stain, the interface necroinflammation consists primarily of lymphocytes with plasma cells (C); the dense periductal lymphocyte infiltrate (D) and the hepatic rosette formation (black circle) were well observed with Masson stain (E). Feathery degeneration of hepatocyte (red arrow) and hepatic cholestasis (black arrow) were also observed (F) (×200 hematoxylin and eosin stain). (G) Trends of liver function tests, total bilirubin, and total IgG levels over time. Dashed lines are the respective lower limit of the normal range of each test. ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma‐glutamyltransferase; TB, total bilirubin; UDCA, ursodeoxycholic acid
See this image and copyright information in PMC

Comment on

References

    1. Palla P, Vergadis C, Sakellariou S, Androutsakos T. Letter to the editor: Autoimmune hepatitis after COVID‐19 vaccination. A rare adverse effect? Hepatology. 2021. 10.1002/hep.32156 - DOI - PMC - PubMed
    1. Mungmunpuntipantip R, Wiwanitkit V. Lettter to the editor on “Autoimmune hepatitis after COVID‐19 vaccination.” Hepatology. 2021. 10.1002/hep.32249 - DOI - PMC - PubMed
    1. Bril F. Autoimmune hepatitis developing after coronavirus disease 2019 (COVID‐19) vaccine: one or even several swallows do not make a summer. J Hepatol. 2021;75:1256–7. - PMC - PubMed
    1. Medeiros‐Ribeiro AC, Aikawa NE, Saad CGS, Yuki EFN, Pedrosa T, Fusco SRG, et al. Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial. Nat Med. 2021;27:1744–51. - PubMed

Substances