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. 2022 Feb;10(2):397-408.
doi: 10.1016/j.jaip.2021.11.016. Epub 2021 Dec 1.

The Role of Comorbidities in Difficult-to-Control Asthma in Adults and Children

Jonathan M Gaffin  1 , Mario Castro  2 , Leonard B Bacharier  3 , Anne L Fuhlbrigge  4
Affiliations

The Role of Comorbidities in Difficult-to-Control Asthma in Adults and Children

Jonathan M Gaffin et al. J Allergy Clin Immunol Pract. 2022 Feb.

Abstract

Assessment of asthma comorbidities, conditions that adversely affect the pathobiology of asthma or impair its response to therapies, is a fundamental step in the evaluation and management of patients with difficult-to-treat asthma. Identifying and effectively treating asthma comorbidities, such as obesity, obstructive sleep apnea, and chronic sinusitis with nasal polyps, may improve asthma control and reduce exacerbations. In addition, identifying comorbid T2 inflammatory conditions may help guide optimal selection of biologic therapies. Here, we describe common comorbid conditions found in adult and pediatric difficult-to-control asthma, discuss evidence for the association with asthma morbidity and treatment benefit, and provide information on how and when to assess comorbidities.

Keywords: Adults; Children; Comorbidities; Difficult-to-control asthma.

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Figures

Figure 1.
Figure 1.. Flow diagram for recommended evaluation of comorbidities in patients with Difficult to Control asthma
CRSsNP, chronic rhinosinusitis without nasal polyps; CRSwNP, chronic rhinosinusitis with nasal polyps;ILO, inducible laryngeal obstruction; OSA, obstructive sleep apnea; GERD, gastroesophageal reflux; SPT, skin prick testing; sIgE, specific immunoglobulin E; CT, computed tomography; BMI, body mass index; SEBQ, Self-Evaluation of Breathing Questionnaire; GI, gastroenterology; PSG, polysomnography; ABPA, allergic bronchopulmonary aspergillosis; IgE, immunoglobulin E; sIgG, specific Immunoglobulin G.
See this image and copyright information in PMC

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