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. 2022 Feb 17;139(7):1111-1115.
doi: 10.1182/blood.2021012756.

Diminished ovarian reserve in young women with sickle cell anemia

Lydia H Pecker  1   2 , Sarah Hussain  1 , Jaanvi Mahesh  1 , Ravi Varadhan  3 , Mindy S Christianson  2   4 , Sophie Lanzkron  1
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Diminished ovarian reserve in young women with sickle cell anemia

Lydia H Pecker et al. Blood. .

Abstract

Women with sickle cell anemia (SCA) have higher rates of diminished ovarian reserve (DOR) than age-matched controls. Pecker et al report a small study of patients with SCA that compares ovarian reserve in patients after stem cell transplant, on therapy with hydroxyurea (HU), and on supportive care. As expected, patients who received transplants have severe DOR. About one-third of patients on HU have DOR, while DOR was absent in patients on supportive care. Whether this reflects an impact of HU or is a biomarker of severe disease remains to be established in a larger study.

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