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. 2022 Feb 17;139(7):1111-1115.
doi: 10.1182/blood.2021012756.

Diminished ovarian reserve in young women with sickle cell anemia

Lydia H Pecker  1   2 , Sarah Hussain  1 , Jaanvi Mahesh  1 , Ravi Varadhan  3 , Mindy S Christianson  2   4 , Sophie Lanzkron  1
Affiliations

Diminished ovarian reserve in young women with sickle cell anemia

Lydia H Pecker et al. Blood. .

Abstract

Women with sickle cell anemia (SCA) have higher rates of diminished ovarian reserve (DOR) than age-matched controls. Pecker et al report a small study of patients with SCA that compares ovarian reserve in patients after stem cell transplant, on therapy with hydroxyurea (HU), and on supportive care. As expected, patients who received transplants have severe DOR. About one-third of patients on HU have DOR, while DOR was absent in patients on supportive care. Whether this reflects an impact of HU or is a biomarker of severe disease remains to be established in a larger study.

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References

    1. Pecker LH, Sharma D, Nero A, et al. . Knowledge gaps in reproductive and sexual health in girls and women with sickle cell disease. Br J Haematol. 2021;194(6):970-979. - PMC - PubMed
    1. Rasool S, Shah D. Fertility with early reduction of ovarian reserve: the last straw that breaks the Camel’s back. Fertil Res Pract. 2017;3(1):15. - PMC - PubMed
    1. Hofmann GE, Khoury J, Thie J. Recurrent pregnancy loss and diminished ovarian reserve. Fertil Steril. 2000;74(6):1192-1195. - PubMed
    1. Lyttle Schumacher BM, Jukic AMZ, Steiner AZ. Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies. Fertil Steril. 2018;109(6):1065-1071.e1. - PMC - PubMed
    1. Tremellen K, Savulescu J. Ovarian reserve screening: a scientific and ethical analysis. Hum Reprod. 2014;29(12):2606-2614. - PubMed

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