Faraway, so close: Intratumoral heterogeneity of medulloblastoma subgroups

Affiliations

¹ Department of Surgery, Division of Orthopedic Surgery, Cancer Research Program, Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada.

Editorial

Livia Garzia. Neuro Oncol. 2022.

. 2022 Feb 1;24(2):287-288.

doi: 10.1093/neuonc/noab281.

¹ Department of Surgery, Division of Orthopedic Surgery, Cancer Research Program, Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada.

No abstract available

Comment on

Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.
Riemondy KA, Venkataraman S, Willard N, Nellan A, Sanford B, Griesinger AM, Amani V, Mitra S, Hankinson TC, Handler MH, Sill M, Ocasio J, Weir SJ, Malawsky DS, Gershon TR, Garancher A, Wechsler-Reya RJ, Hesselberth JR, Foreman NK, Donson AM, Vibhakar R. Riemondy KA, et al. Neuro Oncol. 2022 Feb 1;24(2):273-286. doi: 10.1093/neuonc/noab135. Neuro Oncol. 2022. PMID: 34077540 Free PMC article.

1. Riemondy KA, Venkataraman S, Willard N, et al. . Neoplastic and immune single cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma. Neuro Oncol. 2022;24(2),273–286. - PMC - PubMed
1. Vladoiu MC, El-Hamamy I, Donovan LK, et al. . Childhood cerebellar tumours mirror conserved fetal transcriptional programs. Nature. 2019;572(7767):67–73. - PMC - PubMed
1. Hovestadt V, Smith KS, Bihannic L, et al. . Resolving medulloblastoma cellular architecture by single-cell genomics. Nature. 2019;572(7767):74–79. - PMC - PubMed
1. Ellison DW, Dalton J, Kocak M, et al. . Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta Neuropathol. 2011;121(3):381–396. - PMC - PubMed
1. Cheng Y, Liao S, Xu G, et al. . NeuroD1 dictates tumor cell differentiation in medulloblastoma. Cell Rep. 2020;31(12):107782. - PMC - PubMed