Recent advances in tissue stem cells

Xin Fu^#¹, Qiang He^#², Yu Tao^#², Mengdi Wang^#^{3

4}, Wei Wang^#^{3

4}, Yalong Wang^#⁵, Qing Cissy Yu^#², Fang Zhang^#², Xiaoyu Zhang^#^{2

4}, Ye-Guang Chen^{6

7}, Dong Gao^{8

9

10}, Ping Hu^{11

12

13

14

15}, Lijian Hui^{16

17

18

19

20}, Xiaoqun Wang^{21

22

23

24}, Yi Arial Zeng^{25

26

27}

Affiliations

¹ Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200233, China.
² State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
³ State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Bioland Laboratory (Guangzhou), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
⁴ University of Chinese Academy of Sciences, Beijing, 100049, China.
⁵ The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
⁶ The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China. ygchen@tsinghua.edu.cn.
⁷ Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510530, China. ygchen@tsinghua.edu.cn.
⁸ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. dong.gao@sibcb.ac.cn.
⁹ University of Chinese Academy of Sciences, Beijing, 100049, China. dong.gao@sibcb.ac.cn.
¹⁰ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. dong.gao@sibcb.ac.cn.
¹¹ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. hup@sibcb.ac.cn.
¹² Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200233, China. hup@sibcb.ac.cn.
¹³ Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510530, China. hup@sibcb.ac.cn.
¹⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. hup@sibcb.ac.cn.
¹⁵ Bio-Research Innovation Center, Shanghai Institute of Biochemistry and Cell Biology, Suzhou, 215121, China. hup@sibcb.ac.cn.
¹⁶ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. ljhui@sibcb.ac.cn.
¹⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ljhui@sibcb.ac.cn.
¹⁸ Bio-Research Innovation Center, Shanghai Institute of Biochemistry and Cell Biology, Suzhou, 215121, China. ljhui@sibcb.ac.cn.
¹⁹ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. ljhui@sibcb.ac.cn.
²⁰ School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, 310024, China. ljhui@sibcb.ac.cn.
²¹ State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Bioland Laboratory (Guangzhou), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. xiaoqunwang@ibp.ac.cn.
²² University of Chinese Academy of Sciences, Beijing, 100049, China. xiaoqunwang@ibp.ac.cn.
²³ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. xiaoqunwang@ibp.ac.cn.
²⁴ Advanced Innovation Center for Human Brain Protection, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China. xiaoqunwang@ibp.ac.cn.
²⁵ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. yzeng@sibcb.ac.cn.
²⁶ Bio-Research Innovation Center, Shanghai Institute of Biochemistry and Cell Biology, Suzhou, 215121, China. yzeng@sibcb.ac.cn.
²⁷ School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, 310024, China. yzeng@sibcb.ac.cn.

^# Contributed equally.

PMID: 34865207
DOI: 10.1007/s11427-021-2007-8

Review

Recent advances in tissue stem cells

Xin Fu et al. Sci China Life Sci. 2021 Dec.

. 2021 Dec;64(12):1998-2029.

doi: 10.1007/s11427-021-2007-8. Epub 2021 Nov 30.

Authors

Affiliations

¹ Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200233, China.
² State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
³ State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Bioland Laboratory (Guangzhou), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
⁴ University of Chinese Academy of Sciences, Beijing, 100049, China.
⁵ The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
⁶ The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China. ygchen@tsinghua.edu.cn.
⁷ Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510530, China. ygchen@tsinghua.edu.cn.
⁸ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. dong.gao@sibcb.ac.cn.
⁹ University of Chinese Academy of Sciences, Beijing, 100049, China. dong.gao@sibcb.ac.cn.
¹⁰ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. dong.gao@sibcb.ac.cn.
¹¹ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. hup@sibcb.ac.cn.
¹² Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200233, China. hup@sibcb.ac.cn.
¹³ Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510530, China. hup@sibcb.ac.cn.
¹⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. hup@sibcb.ac.cn.
¹⁵ Bio-Research Innovation Center, Shanghai Institute of Biochemistry and Cell Biology, Suzhou, 215121, China. hup@sibcb.ac.cn.
¹⁶ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. ljhui@sibcb.ac.cn.
¹⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ljhui@sibcb.ac.cn.
¹⁸ Bio-Research Innovation Center, Shanghai Institute of Biochemistry and Cell Biology, Suzhou, 215121, China. ljhui@sibcb.ac.cn.
¹⁹ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. ljhui@sibcb.ac.cn.
²⁰ School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, 310024, China. ljhui@sibcb.ac.cn.
²¹ State Key Laboratory of Brain and Cognitive Science, CAS Center for Excellence in Brain Science and Intelligence Technology, Bioland Laboratory (Guangzhou), Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China. xiaoqunwang@ibp.ac.cn.
²² University of Chinese Academy of Sciences, Beijing, 100049, China. xiaoqunwang@ibp.ac.cn.
²³ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. xiaoqunwang@ibp.ac.cn.
²⁴ Advanced Innovation Center for Human Brain Protection, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100069, China. xiaoqunwang@ibp.ac.cn.
²⁵ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. yzeng@sibcb.ac.cn.
²⁶ Bio-Research Innovation Center, Shanghai Institute of Biochemistry and Cell Biology, Suzhou, 215121, China. yzeng@sibcb.ac.cn.
²⁷ School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou, 310024, China. yzeng@sibcb.ac.cn.

^# Contributed equally.

PMID: 34865207
DOI: 10.1007/s11427-021-2007-8

Abstract

Stem cells are undifferentiated cells capable of self-renewal and differentiation, giving rise to specialized functional cells. Stem cells are of pivotal importance for organ and tissue development, homeostasis, and injury and disease repair. Tissue-specific stem cells are a rare population residing in specific tissues and present powerful potential for regeneration when required. They are usually named based on the resident tissue, such as hematopoietic stem cells and germline stem cells. This review discusses the recent advances in stem cells of various tissues, including neural stem cells, muscle stem cells, liver progenitors, pancreatic islet stem/progenitor cells, intestinal stem cells, and prostate stem cells, and the future perspectives for tissue stem cell research.

Keywords: intestinal stem cells; liver progenitors; muscle stem cells; neural stem cells; pancreatic islet stem/progenitor cells; prostate stem cells.

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Recent advances in tissue stem cells

Affiliations

Recent advances in tissue stem cells

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Medical