l-asparaginase: Need for an Expedition from an Enzymatic Molecule to Antimicrobial Drug

Abstract

Enzymes play a vital role in the biological system as a catalyst for biochemical reactions. They have a wide range of commercial applications in many areas like the pharmaceutical industry, food industry, etc. l-asparaginase is one of the commercial enzymes with prime importance in anticancer therapy. It is mainly used in chemotherapy; however, it has the potential to cure autoimmune disorders and infectious diseases also. Previous studies reported the antimicrobial potential of l-asparaginase. Therefore, we have discussed the possibility and challenges of the antimicrobial application of l-asparaginase in the treatment of infectious diseases. This is followed by a discussion on the effective delivery of this enzyme using biopolymeric nanocarriers that ensure safe and on target action. The present article gives a perspective on the l-asparaginase molecule that could be developed/established as an approved antimicrobial drug in the future.

Keywords: Antimicrobial potential; Biopolymeric nano-delivery; Experimental molecule; Futuristic antimicrobial drug; l-asparaginase.

Fig. 1

Strength, opportunity, weakness, processes, and possible rationale in the development of l-asparaginase as a futuristic antimicrobial drug

Fig. 2

Suggested action mechanism of l-asparaginase on bacterial cell wall disruption