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Review
. 2021 Nov 16:15:755902.
doi: 10.3389/fnins.2021.755902. eCollection 2021.

Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury

Xianhui Kang  1   2 , Shuyue Su  3 , Wandong Hong  4 , Wujun Geng  1   5 , Hongli Tang  1
Affiliations
Review

Research Progress on the Ability of Astragaloside IV to Protect the Brain Against Ischemia-Reperfusion Injury

Xianhui Kang et al. Front Neurosci. .

Abstract

Stroke, a disease with a sudden onset and high morbidity and mortality rates, is difficult to treat in the clinic. Traditional Chinese medicine has become increasingly widely used in clinical practice. Modern pharmacological studies have found that Radix Astragali has a variety of medicinal properties, i.e., immunoregulatory, antioxidative, anti-cancer, anti-diabetes, myocardial protective, hepatoprotective, and antiviral functions. This article reviews the protective effect and mechanism of astragaloside IV, which is extracted from Radix Astragali, on stroke, discusses the cerebroprotective effect of astragaloside IV against ischemia-reperfusion-related complications, offers insight into research prospects, and expands the idea of integrating traditional Chinese and Western medicine treatment strategies and drugs to provide a theoretical reference for the clinical treatment of cerebral ischemia-reperfusion injury and the improvement of stroke prognosis.

Keywords: Radix Astragali; astragaloside-IV; cerebral protection; ischemia reperfusion; stroke.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Chemical structure of Astragaloside IV.
FIGURE 2
FIGURE 2
Astragaloside IV can preserve mitochondrial HK-II and subsequently protect neurons from apoptosis and cell death by promoting the binding of Akt to HK-II, which activates Akt and protects mitochondrial HK-II, improving glycolysis, and protecting hexokinase (Springer).
FIGURE 3
FIGURE 3
Antioxidative stress mechanism of astragaloside IV.
FIGURE 4
FIGURE 4
Astragaloside IV reverses microglial polarization, reduces the inflammatory response, ameliorates neuronal injury, and promotes the regeneration of neurons and the repair of brain tissue.
See this image and copyright information in PMC

References

    1. Abdullahi W., Tripathi D., Ronaldson P. T. (2018). Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection. Am. J. Physiol. 315 C343–C356. 10.1152/ajpcell.00095.2018 - DOI - PMC - PubMed
    1. Agre P. (2006). The aquaporin water channels. Proc. Am. Thorac. Soc. 3 5–13. 10.1513/pats.200510-109JH - DOI - PMC - PubMed
    1. Ai P., Yong G., Dingkun G., Qiuyu Z., Kaiyuan Z., Shanyan L. (2008). Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide. J. Ethnopharmacol. 116 413–421. 10.1016/j.jep.2007.12.005 - DOI - PubMed
    1. Alano C. C., Ying W., Swanson R. A. (2004). Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition. J. Biol. Chem. 279 18895–18902. 10.1074/jbc.M313329200 - DOI - PubMed
    1. Armstead W. M., Ganguly K., Kiessling J. W., Riley J., Chen X. H., Smith D. H., et al. (2010). Signaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders. J. Neurochem. 113 303–312. 10.1111/j.1471-4159.2010.06613.x - DOI - PMC - PubMed

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