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. 2021 Nov 11:12:705376.
doi: 10.3389/fphar.2021.705376. eCollection 2021.

Progress and Research Trends on Catha edulis (Vahl) Endl. (Catha edulis): A Review and Bibliometric Analysis

Shuang Ye  1 , Jin Hu  2 , Zilong Liu  1 , Man Liang  1
Affiliations

Progress and Research Trends on Catha edulis (Vahl) Endl. (Catha edulis): A Review and Bibliometric Analysis

Shuang Ye et al. Front Pharmacol. .

Abstract

Catha edulis (Vahl) Endl., known as Catha edulis or Khat is a traditional and regional plant for chewing, smoking and drinking, that has posed a worldwide public health problem due to its recent emerging abused consumption. In the face of the massive use of Catha edulis, we reviewed related publications to analyze the progress and research trends through bibliometric methods. After screening, a total of 514 scientific publications published from 1997 to 2020 were included by systematic retrieval from the Web of Science (WoS) database. According to further scientometric analysis, the annual number of publications output kept rising in most of the years. Ethiopia and the United States of America (USA) have been devoting significant contributions to the field. Though the research emphasis had been the chemical composition and pharmacological and toxicological effects for several years, the hot spots were transferred; the mechanism investigations of Catha edulis have been the focus in recent years, which might be continued in the future. Furthermore, co-operations of multi-disciplinary researchers are needed to minimize abuse harms and maximize the medicinal benefits of Catha edulis to human beings.

Keywords: Catha edulis; Catha edulis (vahl) endl.; bibliometric analysis; cathinone; chemical composition; mechanisms; pharmacological effect; toxicology.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The flow chart of database construction.
FIGURE 2
FIGURE 2
Annual number and accumulated number of Catha edulis publications from 1997 to 2020.
FIGURE 3
FIGURE 3
Cooperation between contributed countries.
FIGURE 4
FIGURE 4
Network of keywords co-occurrence. The cross size and the link each illustrated the frequency and relevance of keywords.
FIGURE 5
FIGURE 5
Co-cited references timeline map of Catha edulis. Nodes on the map represent referenced documents. The size of nodes represents the frequencies of cited references, and the location reflects the present time. And years are arranged horizontally at the top. The clusters are performed based on the themes of co-cited references and the label of each cluster is shown at the end of the timeline.
FIGURE 6
FIGURE 6
Top 20 keywords with the strongest citation bursts. Each blue or red short line represents a year, and a red line stands for a burst detected year.
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