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Case Reports
. 2021:34:101560.
doi: 10.1016/j.rmcr.2021.101560. Epub 2021 Nov 29.

Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report

Ayham Daher  1 , Tobias Müller  1 , Jens Spiesshoefer  1 , Michael Dreher  1 , Jens Panse  2
Affiliations
Case Reports

Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report

Ayham Daher et al. Respir Med Case Rep. 2021.

Abstract

A 71-year-old female patient with B-cell depletion due to treatment with an anti-CD20 monoclonal antibody was admitted for worsening COVID-19. Overall, she had persistent viral shedding, worsening respiratory failure, and progressive pneumonia that did not improve despite dexamethasone and antibiotic therapy. After administration of bamlanivimab, a monoclonal antibody with high affinity for the receptor-binding domain of the SARS-CoV-2 spike protein, inflammatory markers rapidly decreased, SARS-CoV2 RT-PCR became negative, and the patient improved clinically and radiologically. In conclusion, we demonstrated successful treatment of prolonged COVID-19 in a patient with severe B-cell aplasia with a virus-neutralizing monoclonal antibody.

Keywords: B-Cell aplasia; BMI, body-mass index; COVID-19; COVID-19, Coronavirus Disease 2019; CRP, C-reactive protein; CT, computed tomography; ICU, intensive care unit; IL-2, interleukin 2; Immunodeficiency; Monoclonal antibodies; NK, natural killer; SARS-CoV-2, severe acute respiratory syndrome coronavirus type 2; TNF-alpha, Tumor necrosis factor.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Imaging studies of the chest.
See this image and copyright information in PMC

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