Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis

doi:10.5409/wjcp.v10.i6.168

. 2021 Nov 9;10(6):168-176.

doi: 10.5409/wjcp.v10.i6.168.

Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis

Evanthia Perikleous¹, Sotirios Fouzas², Athina Karageorgiou³, Paschalis Steiropoulos⁴, Evangelia Nena⁵, Athanasios Chatzimichael³, Aggelos Tsalkidis³, Emmanouil Paraskakis⁶

Affiliations

¹ Department of Pediatrics, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupoli 68100, Greece. eviperikleous@hotmail.com.
² Department of Paediatrics, University Hospital of Patras, University of Patras, Patra 26504, Greece.
³ Department of Pediatrics, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupoli 68100, Greece.
⁴ Department of Pneumonology, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupoli 68100, Greece.
⁵ Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, Alexandroupoli 68100, Greece.
⁶ Paediatric Respiratory Unit, Paediatric Department, University of Crete, Heraklion 71500, Greece.

PMID: 34868893
PMCID: PMC8603642
DOI: 10.5409/wjcp.v10.i6.168

Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis

Evanthia Perikleous et al. World J Clin Pediatr. 2021.

. 2021 Nov 9;10(6):168-176.

doi: 10.5409/wjcp.v10.i6.168.

Authors

Evanthia Perikleous¹, Sotirios Fouzas², Athina Karageorgiou³, Paschalis Steiropoulos⁴, Evangelia Nena⁵, Athanasios Chatzimichael³, Aggelos Tsalkidis³, Emmanouil Paraskakis⁶

Affiliations

¹ Department of Pediatrics, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupoli 68100, Greece. eviperikleous@hotmail.com.
² Department of Paediatrics, University Hospital of Patras, University of Patras, Patra 26504, Greece.
³ Department of Pediatrics, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupoli 68100, Greece.
⁴ Department of Pneumonology, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupoli 68100, Greece.
⁵ Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, Alexandroupoli 68100, Greece.
⁶ Paediatric Respiratory Unit, Paediatric Department, University of Crete, Heraklion 71500, Greece.

PMID: 34868893
PMCID: PMC8603642
DOI: 10.5409/wjcp.v10.i6.168

Abstract

Background: Tidal breathing flow-volume (TBFV) analysis provides important information about lung mechanics in infants.

Aim: To assess the effects of breastfeeding on the TBFV measurements of infants who recover from acute bronchiolitis.

Methods: In this cross-sectional study, TBFV analysis was performed in infants with bronchiolitis prior to hospital discharge. The ratio of time to peak expiratory flow to total expiratory time (tPEF/tE) at baseline and after the administration of 400 mcg salbutamol was evaluated.

Results: A total of 56 infants (35 boys), aged 7.4 ± 2.8 mo, were included. Of them, 12.5% were exposed to tobacco smoke and 41.1% were breastfed less than 2 mo. There were no differences in baseline TBFV measurements between the breastfeeding groups; however, those who breastfed longer than 2 mo had a greater change in tPEF/tE after bronchodilation (12% ± 10.4% vs 0.9% ± 7.1%; P < 0.001). Moreover, there was a clear dose-response relationship between tPEF/tE reversibility and duration of breastfeeding (P < 0.001). In multivariate regression analysis, infants who breastfed less (regression coefficient -0.335, P = 0.010) or were exposed to cigarette smoke (regression coefficient 0.353, P = 0.007) showed a greater change in tPEF/tE after bronchodilation, independent of sex, prematurity, and family history of asthma or atopy.

Conclusion: Infants who recover from bronchiolitis and have a shorter duration of breastfeeding or are exposed to cigarette smoke, have TBFV measurements indicative of obstructive lung disease.

Keywords: Breastfeeding; Bronchiolitis; Cigarette smoke; Infants; Lung function; Tidal breathing analysis.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

**Figure 1**
**Percent change in time to peak expiratory flow to total expiratory time after bronchodilation in relation to breastfeeding and smoking exposure.** A: Breastfeeding; B: Smoking exposure. BF: Breastfeeding; tPEF/tE: Time to peak expiratory flow to total expiratory time.

**Figure 2**
**Percent change in time to peak expiratory flow to total expiratory time after bronchodilation in relation to the duration of breastfeeding.** BF: Breastfeeding; tPEF/tE: Time to peak expiratory flow to total expiratory time.

See this image and copyright information in PMC

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[1] Ali S, Plint AC, Klassen TP. Bronchiolitis. In: Wilmott RW, Kendig EL, Boat TF, Bush A, Chernick V. Kendig and Chernick’s disorders of the respiratory tract in children, 8th ed. Philadelphia: Elsevier Saunders, 2012: 443-452.

[2] Ali S, Plint AC, Klassen TP. Bronchiolitis. In: Wilmott RW, Kendig EL, Boat TF, Bush A, Chernick V. Kendig and Chernick’s disorders of the respiratory tract in children, 8th ed. Philadelphia: Elsevier Saunders, 2012: 443-452.

[5] Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM, Johnson DW, Light MJ, Maraqa NF, Mendonca EA, Phelan KJ, Zorc JJ, Stanko-Lopp D, Brown MA, Nathanson I, Rosenblum E, Sayles S 3rd, Hernandez-Cancio S American Academy of Pediatrics. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014;134:e1474–e1502. - PubMed

[6] Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM, Johnson DW, Light MJ, Maraqa NF, Mendonca EA, Phelan KJ, Zorc JJ, Stanko-Lopp D, Brown MA, Nathanson I, Rosenblum E, Sayles S 3rd, Hernandez-Cancio S American Academy of Pediatrics. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014;134:e1474–e1502. - PubMed

[7] Nenna R, Cutrera R, Frassanito A, Alessandroni C, Nicolai A, Cangiano G, Petrarca L, Arima S, Caggiano S, Ullmann N, Papoff P, Bonci E, Moretti C, Midulla F. Modifiable risk factors associated with bronchiolitis. Ther Adv Respir Dis. 2017;11:393–401. - PMC - PubMed

[8] Nenna R, Cutrera R, Frassanito A, Alessandroni C, Nicolai A, Cangiano G, Petrarca L, Arima S, Caggiano S, Ullmann N, Papoff P, Bonci E, Moretti C, Midulla F. Modifiable risk factors associated with bronchiolitis. Ther Adv Respir Dis. 2017;11:393–401. - PMC - PubMed

[9] Davisse-Paturet C, Adel-Patient K, Forhan A, Lioret S, Annesi-Maesano I, Heude B, Charles MA, de Lauzon-Guillain B. Breastfeeding initiation or duration and longitudinal patterns of infections up to 2 years and skin rash and respiratory symptoms up to 8 years in the EDEN mother-child cohort. Matern Child Nutr. 2020;16:e12935. - PMC - PubMed

[10] Davisse-Paturet C, Adel-Patient K, Forhan A, Lioret S, Annesi-Maesano I, Heude B, Charles MA, de Lauzon-Guillain B. Breastfeeding initiation or duration and longitudinal patterns of infections up to 2 years and skin rash and respiratory symptoms up to 8 years in the EDEN mother-child cohort. Matern Child Nutr. 2020;16:e12935. - PMC - PubMed

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Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis

Affiliations

Association of breastfeeding with tidal breathing analysis in infants with bronchiolitis

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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References

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Abstract

Conflict of interest statement

Figures

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References

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