Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Nov 25:2021:9994734.
doi: 10.1155/2021/9994734. eCollection 2021.

Microbiome and Gestational Diabetes: Interactions with Pregnancy Outcome and Long-Term Infant Health

Caterina Neri  1 , Erika Serafino  1 , Maddalena Morlando  2 , Alessandra Familiari  1
Affiliations
Review

Microbiome and Gestational Diabetes: Interactions with Pregnancy Outcome and Long-Term Infant Health

Caterina Neri et al. J Diabetes Res. .

Abstract

Microbiota composition is progressively being connected to different physiologic effects, such as glucose metabolism, and also to different pathologies, such as gestational diabetes mellitus (GDM). GDM is a public health concern that affects an important percentage of pregnancies and is correlated with many adverse maternal and neonatal outcomes. An increasing number of studies are showing some connections between specific microbial composition of the gut microbiota and development of GDM and adverse outcomes in mothers and neonates. The aim of this review is to analyze the available data on microbial changes that characterize healthy pregnancies and pregnancies complicated by GDM and to understand the correlation of these changes with adverse maternal outcomes; this review will also discuss the consequences of these maternal gut microbiome alterations on neonatal microbiota composition and neonatal long-term outcomes.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Differences in the gut microbiota between a nonpregnant woman and healthy pregnancy.
Figure 2
Figure 2
Differences in the gut microbiota between healthy pregnancy and GDM pregnancy.
See this image and copyright information in PMC

References

    1. Whitman W. B., Coleman D. C., Wiebe W. J. Prokaryotes: the unseen majority. Proceedings of the National Academy of Sciences . 1998;95:6578–6583. - PMC - PubMed
    1. The NIH HMP Working Group, Peterson J., Garges S., et al. The NIH human microbiome project. Genome Research . 2009;19(12):2317–2323. doi: 10.1101/gr.096651.109. - DOI - PMC - PubMed
    1. Gill S. R., Pop M., DeBoy R. T., et al. Metagenomic analysis of the human distal gut microbiome. Science . 2006;312(5778):1355–1359. doi: 10.1126/science.1124234. - DOI - PMC - PubMed
    1. MetaHIT Consortium, Qin J., Li R., et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature . 2010;464(7285):59–65. doi: 10.1038/nature08821. - DOI - PMC - PubMed
    1. Zhu B., Wang X., Li L. Human gut microbiome: the second genome of human body. Protein & cell . 2010;1:718–725. - PMC - PubMed

LinkOut - more resources