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. 2022 Mar:26:101448.
doi: 10.1016/j.genrep.2021.101448. Epub 2021 Nov 27.

Evaluation of biochemical characteristics of 183 COVID-19 patients: A retrospective study

Seyed Mostafa Mir  1 , Alireza Tahamtan  2   3 , Hadi Razavi Nikoo  2   3 , Mehdi Sheikh Arabi  4 , Abdul Wahab Moradi  2   3 , Saeed Ardakanian  1 , Alijan Tabarraei  2   3
Affiliations

Evaluation of biochemical characteristics of 183 COVID-19 patients: A retrospective study

Seyed Mostafa Mir et al. Gene Rep. 2022 Mar.

Abstract

Introduction and aim: Coronavirus disease 2019 (COVID-19), with a high mortality rate, has caught the eyes of researchers worldwide and placed a heavy burden on the health care system. Accordingly, this study aimed to evaluate the values of biochemical parameters on the outcomes of COVID-19 patients in Golestan, Iran.

Materials and methods: This retrospective study was conducted on 183 COVID-19 patients (i.e., 94 males and 89 females) between March and September 2020. The biochemical parameters and demographic data of the patients (including age, sex, urea, creatinine [Cr], lactate dehydrogenase [LDH], and creatine kinase [CK]) were obtained from electrical medical records. According to the outcome of COVID-19, the patients were categorized into two groups (i.e., death [n = 63] and survival [n = 120] groups), and the biochemical parameters and outcomes of COVID-19 were analyzed.

Results: Of the 183 patients, 120 (65.5%) had a non-severe type and recovered from COVID-19, and 63 (34.4%) developed into a critically severe type and died. The mean age of all patients was 56.5 years old. The highest mortality was observed in patients with LDH ≥280. The data obtained by the one-sample t-test showed that there were significantly higher mean values of urea, Cr, CK, and LDH in COVID-19 patients when compared to their reference intervals (P˂0.0001 for all).

Conclusions: Some biochemical parameters are effective in the evaluation of dynamic variations in COVID-19 patients. It can be concluded from the results that biochemical parameters and reinforce LDH may be useful for the evaluation of the COVID-19 outcome.

Keywords: Biochemical parameters; COVID-19; Golestan.

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Conflict of interest statement

All authors (Seyed Mostafa Mir, Alireza Tahamtan, Hadi Razavi Nikoo, Mehdi Sheikh Arabi, Abdul Wahab Moradi, Alijan Tabarraei) have approved the manuscript and agree with submission. The authors declare that there are no conflicts of interest to the publication of this article, financial and/or otherwise. The final manuscript has been seen and approved by all authors and that they have taken due care to ensure the integrity of the work. The authors declare that there is no conflict of interest.

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