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. 2022 Feb 15;66(2):e0194921.
doi: 10.1128/AAC.01949-21. Epub 2021 Dec 6.

Azithromycin Resistance in Shiga Toxin-Producing Escherichia coli in France between 2004 and 2020 and Detection of mef(C)- mph(G) Genes

Etienne Bizot #  1 , Aurélie Cointe #  1   2 , Philippe Bidet  1   2 , Patricia Mariani-Kurkdjian  1 , Claire Amaris Hobson  2 , Céline Courroux  1 , Sandrine Liguori  1 , Antoine Bridier-Nahmias  2 , Mélanie Magnan  2 , Manel Merimèche  2   3 , François Caméléna  2   3 , Béatrice Berçot  2   3 , François-Xavier Weill  4 , Sophie Lefèvre  4 , Stéphane Bonacorsi  1   2 , André Birgy  1   2
Affiliations

Azithromycin Resistance in Shiga Toxin-Producing Escherichia coli in France between 2004 and 2020 and Detection of mef(C)- mph(G) Genes

Etienne Bizot et al. Antimicrob Agents Chemother. .

Abstract

We described and characterized Shiga-toxin-producing Escherichia coli (STEC) strains with high levels of resistance to azithromycin isolated in France between 2004 and 2020. Nine of 1,715 (0.52%) STEC strains were resistant to azithromycin, with an increase since 2017. One isolate carried a plasmid-borne mef(C)-mph(G) gene combination, described here for the first time for E. coli. Azithromycin resistance, although rare, needs consideration, as this treatment may be useful in cases of STEC infection.

Keywords: EHEC; azithromycin resistance; fosfomycin; macrolide resistance; macrolides; mef(C)-mph(G); mph(A); mph(B); phosphorylases; rifaximin.

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Conflict of interest statement

The authors declare no conflict of interest.

We have no conflicts of interest to declare.

Figures

FIG 1
FIG 1
Annotation of the 202-kb plasmid p45466 from E. coli strain 45466, harboring the mef(C)-mph(G) gene pair involved in macrolide resistance.
See this image and copyright information in PMC

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