Marine natural products as source of new drugs: an updated patent review (July 2018-July 2021)

Abstract

Introduction: Marine natural products have aided as rich sources of new bioactive agents. The multiplicity of marine habitations and exclusive ecological conditions of the sea offer mostly unexploited sources of unique biological and chemical entities. In continuation with the authors' previous publication, the present study reviews recently published patents in correlation to the efforts in finding new therapeutically potent chemical and biological entities from marine organisms.

Areas covered: This review summarizes the progress in the field of marine natural products as therapeutic agents based on an analysis of the patents published after June 2018. We have identified 68 unique patent families related to novel marine natural products for this time period. Patent information pertaining to therapeutic applications and clinical studies has been analyzed and reported.

Expert opinion: Marine organisms are excellent producers of secondary metabolites with diverse structures and pharmacological activities. Cumulative increase in the number of patents published during the last few years justifies the importance of this study for spotting new entities as sources of therapeutic agents. The new compounds have been claimed to show a range of activities predominantly anticancer, antimicrobial, anti-inflammatory, and neuroprotection. Majority of the recent patents have been filed by Chinese inventors, and a number of these patents are still in the prosecution stage.

Keywords: cancer; drug development; marine natural products; new entity; patents.