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. 2022 Feb;18(2):75-76.
doi: 10.1038/s41574-021-00608-9.

Metabolic disorders, COVID-19 and vaccine-breakthrough infections

Norbert Stefan  1   2   3
Affiliations

Metabolic disorders, COVID-19 and vaccine-breakthrough infections

Norbert Stefan. Nat Rev Endocrinol. 2022 Feb.

Abstract

Obesity and impaired metabolic health are important risk factors for severe COVID-19. Novel data indicate that these risk factors might also promote vaccine-breakthrough SARS-CoV-2 infections in fully vaccinated people. Here, these relationships are discussed and post-acute sequelae of COVID-19 that are related to obesity and impaired metabolic health are addressed.

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Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1. Obesity, impaired metabolic health, COVID-19 and vaccine-breakthrough SARS-CoV-2 infection.
Relationships between obesity and impaired metabolic health and morbidity and mortality, based on SARS-CoV-2 infections and vaccine-breakthrough SARS-CoV-2 infections.
See this image and copyright information in PMC

References

    1. Stefan N, Birkenfeld AL, Schulze MB. Global pandemics interconnected - obesity, impaired metabolic health and COVID-19. Nat. Rev. Endocrinol. 2021;17:135–149. doi: 10.1038/s41574-020-00462-1. - DOI - PubMed
    1. COVID-19 Host Genetics Initiative Mapping the human genetic architecture of COVID-19. Nature. 2021 doi: 10.1038/s41586-021-03767-x. - DOI - PMC - PubMed
    1. Gao M, et al. Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study. Lancet Diabetes Endocrinol. 2021;9:350–359. doi: 10.1016/S2213-8587(21)00089-9. - DOI - PMC - PubMed
    1. Codo AC, et al. Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis-dependent axis. Cell Metab. 2020;32:498–499. doi: 10.1016/j.cmet.2020.07.015. - DOI - PMC - PubMed
    1. Tsai S, et al. Insulin receptor-mediated stimulation boosts T cell immunity during inflammation and infection. Cell Metab. 2018;28:922–934. doi: 10.1016/j.cmet.2018.08.003. - DOI - PubMed

Substances

Supplementary concepts