Improving CRISPR tools by elucidating DNA repair

Jung Min Lim¹, Hyongbum Henry Kim^{2

3}

Affiliations

¹ Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea.
² Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea. hkim1@yuhs.ac.
³ Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea. hkim1@yuhs.ac.

Comment

Jung Min Lim et al. Nat Biotechnol. 2021 Dec.

. 2021 Dec;39(12):1512-1514.

doi: 10.1038/s41587-021-01149-2.

Jung Min Lim¹, Hyongbum Henry Kim^{2

3}

¹ Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea.
² Department of Pharmacology, Yonsei University College of Medicine, Seoul, Republic of Korea. hkim1@yuhs.ac.
³ Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea. hkim1@yuhs.ac.

No abstract available

Comment on

Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.
Koblan LW, Arbab M, Shen MW, Hussmann JA, Anzalone AV, Doman JL, Newby GA, Yang D, Mok B, Replogle JM, Xu A, Sisley TA, Weissman JS, Adamson B, Liu DR. Koblan LW, et al. Nat Biotechnol. 2021 Nov;39(11):1414-1425. doi: 10.1038/s41587-021-00938-z. Epub 2021 Jun 28. Nat Biotechnol. 2021. PMID: 34183861 Free PMC article.
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.
Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR. Chen PJ, et al. Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. Epub 2021 Oct 14. Cell. 2021. PMID: 34653350 Free PMC article.
Mapping the genetic landscape of DNA double-strand break repair.
Hussmann JA, Ling J, Ravisankar P, Yan J, Cirincione A, Xu A, Simpson D, Yang D, Bothmer A, Cotta-Ramusino C, Weissman JS, Adamson B. Hussmann JA, et al. Cell. 2021 Oct 28;184(22):5653-5669.e25. doi: 10.1016/j.cell.2021.10.002. Epub 2021 Oct 20. Cell. 2021. PMID: 34672952 Free PMC article.

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