Finding the right KIT inhibitor for advanced systemic mastocytosis

Mariana Castells^{1

2}, Cem Akin³

Affiliations

¹ Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA. mcastells@bwh.harvard.edu.
² Department of Medicine, Harvard Medical School, Boston, MA, USA. mcastells@bwh.harvard.edu.
³ Division of Allergy and Immunology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Comment

Mariana Castells et al. Nat Med. 2021 Dec.

. 2021 Dec;27(12):2081-2082.

doi: 10.1038/s41591-021-01588-z.

Mariana Castells^{1

2}, Cem Akin³

¹ Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, MA, USA. mcastells@bwh.harvard.edu.
² Department of Medicine, Harvard Medical School, Boston, MA, USA. mcastells@bwh.harvard.edu.
³ Division of Allergy and Immunology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

No abstract available

Comment on

Efficacy and safety of avapritinib in advanced systemic mastocytosis: interim analysis of the phase 2 PATHFINDER trial.
Gotlib J, Reiter A, Radia DH, Deininger MW, George TI, Panse J, Vannucchi AM, Platzbecker U, Alvarez-Twose I, Mital A, Hermine O, Dybedal I, Hexner EO, Hicks LK, Span L, Mesa R, Bose P, Pettit KM, Heaney ML, Oh ST, Sen J, Lin HM, Mar BG, DeAngelo DJ. Gotlib J, et al. Nat Med. 2021 Dec;27(12):2192-2199. doi: 10.1038/s41591-021-01539-8. Epub 2021 Dec 6. Nat Med. 2021. PMID: 34873345 Free PMC article.
Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial.
DeAngelo DJ, Radia DH, George TI, Robinson WA, Quiery AT, Drummond MW, Bose P, Hexner EO, Winton EF, Horny HP, Tugnait M, Schmidt-Kittler O, Evans EK, Lin HM, Mar BG, Verstovsek S, Deininger MW, Gotlib J. DeAngelo DJ, et al. Nat Med. 2021 Dec;27(12):2183-2191. doi: 10.1038/s41591-021-01538-9. Epub 2021 Dec 6. Nat Med. 2021. PMID: 34873347 Free PMC article. Clinical Trial.

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