Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Oct 31;13(10):e19164.
doi: 10.7759/cureus.19164. eCollection 2021 Oct.

Vitiligo-Associated Autoimmune Disorders: A Woman With Vitiligo and Incipient Hypothyroidism

Affiliations
Case Reports

Vitiligo-Associated Autoimmune Disorders: A Woman With Vitiligo and Incipient Hypothyroidism

Sara Malik et al. Cureus. .

Abstract

Vitiligo is a skin condition that causes loss of pigmentation, resulting in hypopigmented and depigmented patches on the skin. Vitiligo has been associated with many autoimmune conditions. A 27-year-old female with a history of vitiligo had a clinical presentation and laboratory studies that were consistent with incipient hypothyroidism. The relationship between vitiligo, hypothyroidism, and other autoimmune conditions is discussed.

Keywords: antibodies; autoimmune; hormone; hypothyroidism; melanocyte; stimulating; thyroid; thyroxine; triiodothyronine; vitiligo.

PubMed Disclaimer

Conflict of interest statement

The authors have declared financial relationships, which are detailed in the next section.

Figures

Figure 1
Figure 1. Vitiligo on the right and left thigh
Distant (A) and closer (B) views showing hypopigmentation and depigmentation on the right and left proximal thighs of a 27-year-old female (black stars). The initial site of vitiligo (red star) on her right thigh occurred following the removal of a benign pigmented lesion at the site.
Figure 2
Figure 2. Hypopigmentation and depigmentation on the right and left axilla
Vitiligo affecting the right (A) and left (B) axilla. Larger (black stars) and smaller (black arrows) hypopigmented and depigmented lesions were observed.
Figure 3
Figure 3. Vitiligo on the right flexor wrist
A depigmented patch (black star) on the right flexor wrist of a 27-year-old female; laboratory evaluation demonstrated increased thyroid-stimulating hormone and markedly elevated thyroid peroxidase antibody consisted with incipient hypothyroidism.
Figure 4
Figure 4. Depigmented patch on the right upper eyelid
The depigmented patch of vitiligo (red circle) is located on the right upper eyelid of a 27-year-old female.

References

    1. Vitiligo: mechanisms of pathogenesis and treatment. Frisoli ML, Essien K, Harris JE. Annu Rev Immunol. 2020;38:621–648. - PubMed
    1. JAK-inhibitors in dermatology: current evidence and future applications. Ciechanowicz P, Rakowska A, Sikora M, Rudnicka L. J Dermatolog Treat. 2019;30:648–658. - PubMed
    1. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Bahn RS, Burch HB, Cooper DS, et al. Endocr Pract. 2011;17:456–520. - PubMed
    1. Hypothyroidism: etiology, diagnosis, and management. Almandoz JP, Gharib H. Med Clin North Am. 2012;96:203–221. - PubMed
    1. Vitiligo as the presenting manifestation of Sjogren's syndrome: case report and review of vitiligo and its associated autoimmune conditions. Gutierrez N, Cohen PR. Cureus. 2020;12:0. - PMC - PubMed

Publication types

LinkOut - more resources