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Review
. 2021 Dec 22;41(12):BSR20211577.
doi: 10.1042/BSR20211577.

Deregulation of ribosomal proteins in human cancers

Wendy El Khoury  1 , Zeina Nasr  1
Affiliations
Review

Deregulation of ribosomal proteins in human cancers

Wendy El Khoury et al. Biosci Rep. .

Abstract

The ribosome, the site for protein synthesis, is composed of ribosomal RNAs (rRNAs) and ribosomal proteins (RPs). The latter have been shown to have many ribosomal and extraribosomal functions. RPs are implicated in a variety of pathological processes, especially tumorigenesis and cell transformation. In this review, we will focus on the recent advances that shed light on the effects of RPs deregulation in different types of cancer and their roles in regulating the tumor cell fate.

Keywords: Cancer; Ribosomes; apoptosis; cell survival; metastasis; ribosomal proteins.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. A representation of the most recent findings involving various RPs in the major known oncogenic pathways
See this image and copyright information in PMC

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