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Review
. 2022 Feb;32(1):24-31.
doi: 10.1111/tme.12840. Epub 2021 Dec 7.

Importation of plasma and use of apheresis platelets as risk reduction measures for variant Creutzfeldt-Jakob disease: The SaBTO review

Stephen Thomas  1 , Matthew Katz  2 , Anne-Marie Slowther  3 , Emily Coelho  2 , Gary Mallinson  4 ; Paediatric Components Working Group of the Advisory Committee on the Safety of Blood, Tissues and Organs
Collaborators, Affiliations
Review

Importation of plasma and use of apheresis platelets as risk reduction measures for variant Creutzfeldt-Jakob disease: The SaBTO review

Stephen Thomas et al. Transfus Med. 2022 Feb.

Abstract

Following recognition that blood, blood components, tissues and organs donated by infected donors could transmit infectious prions causing variant Creutzfeldt-Jakob Disease (vCJD), several risk reduction measures were introduced in the UK. The Advisory Committee on the Safety of Blood, Tissues and Organs (SaBTO) established a working group to review the measures in place. Factors considered included: ethical issues around the current provisions and potential changes; operational issues for blood establishments and hospitals; a review from the Advisory Committee on Dangerous Pathogens (ACDP) showing the downward trend in the estimated number of future cases of vCJD; and cost-effectiveness. The working group recommended that the current vCJD risk reduction measures for individuals born after 1995 or with thrombotic thrombocytopenic purpura (TTP) could be withdrawn. After consultation with stakeholders, SaBTO accepted these proposals which allow more equal provision of components, less operational complexity and risk, and more resources to be deployed elsewhere in the NHS. The potential saving on plasma will be £500 m and moving to using pooled platelets in additive solution for all recipients will bring potential savings of £280 m over the next 50 to 60 years. There could be small number of additional clinical cases of vCJD: 1-2 (<1-14; 95% CI) from plasma and 3-4 (<1 to 45; 95% CI) from platelets. Local and national guidelines will still be applied for managing individual conditions. UK Ministers for Health accepted SaBTO's recommendations on 9 Sept 2019 and implementation began immediately. This paper describes the review and rationale leading to these recommendations.

Keywords: SaBTO; blood safety; risk reduction; transfusion; vCJD.

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References

REFERENCES

    1. Food Standards Agency. Bovine Spongiform Encephalopathy (BSE). 2021. Accessed March 15, 2021. https://www.food.gov.uk/safety-hygiene/bovine-spongiform-encephalopathy-bse.
    1. The National CJD Research & Surveillance Unit (NCJDRSU). 2021. Accessed March 15, 2021. https://www.cjd.ed.ac.uk/.
    1. Joint United Kingdom (UK) Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee. Guidelines for the Blood Transfusion Services in the UK. TSO (The Stationery Office); 2021. Accessed March 15, 2021. https://transfusionguidelines.org.uk/.
    1. Scully M, Hunt BJ, Benjamin S, et al. Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies. Br J Haematol. 2012;158(3):323-335. doi:10.1111/j.1365-2141.2012.09167.x
    1. Hewitt PE, Llewelyn CA, Mackenzie J, Will RG. Creutzfeldt-Jakob disease and blood transfusion: results of the UK transfusion medicine epidemiological review study. Vox Sang. 2006;91(3):221-230. doi:10.1111/j.1423-0410.2006.00833.x

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