Review

. 2021 Dec;41(6):1165-1171.

doi: 10.1007/s11596-021-2467-2. Epub 2021 Dec 6.

Type 2 Diabetes Mellitus Easily Develops into Alzheimer's Disease via Hyperglycemia and Insulin Resistance

Ting Li¹, Hong-Xia Cao², Dan Ke³

Affiliations

¹ Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
² Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. 1147467433@qq.com.
³ Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. kedan@mail.hust.edu.cn.

PMID: 34874485
DOI: 10.1007/s11596-021-2467-2

Review

Type 2 Diabetes Mellitus Easily Develops into Alzheimer's Disease via Hyperglycemia and Insulin Resistance

Ting Li et al. Curr Med Sci. 2021 Dec.

. 2021 Dec;41(6):1165-1171.

doi: 10.1007/s11596-021-2467-2. Epub 2021 Dec 6.

Authors

Ting Li¹, Hong-Xia Cao², Dan Ke³

Affiliations

¹ Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
² Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. 1147467433@qq.com.
³ Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. kedan@mail.hust.edu.cn.

PMID: 34874485
DOI: 10.1007/s11596-021-2467-2

Abstract

With the acceleration of population aging, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is progressively increasing due to the age-relatedness of these two diseases. The association between T2DM and AD-like dementia is receiving much attention, and T2DM is reported to be a significant risk factor for AD. The aims of this review were to reveal the brain changes caused by T2DM as well as to explore the roles of hyperglycemia and insulin resistance in the development of AD.

Keywords: Alzheimer’s disease; cognition; hyperglycemia; insulin resistance; type 2 diabetes mellitus.

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Type 2 Diabetes Mellitus Easily Develops into Alzheimer's Disease via Hyperglycemia and Insulin Resistance

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Type 2 Diabetes Mellitus Easily Develops into Alzheimer's Disease via Hyperglycemia and Insulin Resistance

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