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Review
. 2021 Dec;41(6):1165-1171.
doi: 10.1007/s11596-021-2467-2. Epub 2021 Dec 6.

Type 2 Diabetes Mellitus Easily Develops into Alzheimer's Disease via Hyperglycemia and Insulin Resistance

Ting Li  1 , Hong-Xia Cao  2 , Dan Ke  3
Affiliations
Review

Type 2 Diabetes Mellitus Easily Develops into Alzheimer's Disease via Hyperglycemia and Insulin Resistance

Ting Li et al. Curr Med Sci. 2021 Dec.

Abstract

With the acceleration of population aging, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) is progressively increasing due to the age-relatedness of these two diseases. The association between T2DM and AD-like dementia is receiving much attention, and T2DM is reported to be a significant risk factor for AD. The aims of this review were to reveal the brain changes caused by T2DM as well as to explore the roles of hyperglycemia and insulin resistance in the development of AD.

Keywords: Alzheimer’s disease; cognition; hyperglycemia; insulin resistance; type 2 diabetes mellitus.

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