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. 2022 Jan 7;50(D1):D1262-D1272.
doi: 10.1093/nar/gkab1136.

IMGT® databases, related tools and web resources through three main axes of research and development

Taciana Manso  1 , Géraldine Folch  1 , Véronique Giudicelli  1 , Joumana Jabado-Michaloud  1 , Anjana Kushwaha  1 , Viviane Nguefack Ngoune  1 , Maria Georga  1 , Ariadni Papadaki  1 , Chahrazed Debbagh  1 , Perrine Pégorier  1 , Morgane Bertignac  1 , Saida Hadi-Saljoqi  1 , Imène Chentli  1 , Karima Cherouali  1 , Safa Aouinti  1 , Amar El Hamwi  1 , Alexandre Albani  1 , Merouane Elazami Elhassani  1 , Benjamin Viart  1 , Agathe Goret  1 , Anna Tran  1 , Gaoussou Sanou  1 , Maël Rollin  1 , Patrice Duroux  1 , Sofia Kossida  1
Affiliations

IMGT® databases, related tools and web resources through three main axes of research and development

Taciana Manso et al. Nucleic Acids Res. .

Abstract

IMGT®, the international ImMunoGeneTics information system®, http://www.imgt.org/, is at the forefront of the immunogenetics and immunoinformatics fields with more than 30 years of experience. IMGT® makes available databases and tools to the scientific community pertaining to the adaptive immune response, based on the IMGT-ONTOLOGY. We focus on the recent features of the IMGT® databases, tools, reference directories and web resources, within the three main axes of IMGT® research and development. Axis I consists in understanding the adaptive immune response, by deciphering the identification and characterization of the immunoglobulin (IG) and T cell receptor (TR) genes in jawed vertebrates. It is the starting point of the two other axes, namely the analysis and exploration of the expressed IG and TR repertoires based on comparison with IMGT reference directories in normal and pathological situations (Axis II) and the analysis of amino acid changes and functions of 2D and 3D structures of antibody and TR engineering (Axis III).

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Figures

Figure 1.
Figure 1.
IMGT resources. (A) Overview of IMGT databases and tools for genes, sequences and structures. (B) Main databases and datasets in the three axes of IMGT information system.
Figure 2.
Figure 2.
Axis III workflow overview. The left panel displays all analysis processes: the data input panel shows the sources of the data present in the Axis III databases. The data analysis procedure is done by IMGT experts and it includes the analysis of the amino acid sequences and the 3D structures. Data are stored in IMGT/2Dstructure-DB and IMGT/3Dstructure-DB and linked to IMGT/mAb-DB. The right panel shows the user interface that provides flexible ways to query the data sets. The result page panel shows the online tools, such as IMGT/DomainGapAlign (Chain Details) and IMGT/Collier-de-Perles included in IMGT/2Dstructure-DB and Paratope/Epitope description and 3D structure incorporated in IMGT/3Dstructure-DB. IMGT/mAb-DB centralizes the information present in the other databases and adds several metadata for therapeutic proteins.
See this image and copyright information in PMC

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