Achilles tendon ultrasonography in familial hypercholesterolemia: A sub-study of the LIpid transPort disorders Italian GEnetic Network (LIPIGEN)

Andrea Baragetti^{1

2}, Manuela Casula^{2

3}, Paolo Scarinzi⁴, Federica Ristè⁵, Roberto Scicali⁶, Marta Biolo⁴, Simonetta Lugari⁷, Marco Dall'Agata⁵, Marta Gazzotti³, Elena Olmastroni³, Asiiat S Alieva^{3

8}, Fabio Nascimbeni⁷; ACTUS-FH LIPIGEN Substudy¹

Affiliations

¹ Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
² Centre for the Study of Atherosclerosis, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Multimedica Hospital, Sesto San Giovanni, Italy.
³ Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
⁴ U. O. C. Clinica Medica 1, Department of Medicine-DIMED, University of Padua, Padua, Italy.
⁵ U. O. Medicina Interna Universitaria, Institute of Internal Medicine, University of Ferrara, Ferrara, Italy.
⁶ Department of Clinical and Experimental Medicine, Internal Medicine, University of Catania, Catania, Italy.
⁷ Unit of Internal and Metabolic Medicine, Civil Hospital of Baggiovara, A. O. U. of Modena and University of Modena and Reggio Emilia, Modena, Italy.
⁸ Research Laboratory of Lipid Metabolism Disorders and Atherosclerosis, Almazov National Medical Research Centre, St. Petersburg, Russian Federation.

PMID: 34875114
PMCID: PMC9300130
DOI: 10.1111/joim.13421

Achilles tendon ultrasonography in familial hypercholesterolemia: A sub-study of the LIpid transPort disorders Italian GEnetic Network (LIPIGEN)

Andrea Baragetti et al. J Intern Med. 2022 May.

. 2022 May;291(5):702-704.

doi: 10.1111/joim.13421. Epub 2021 Dec 16.

Authors

Affiliations

¹ Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
² Centre for the Study of Atherosclerosis, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) Multimedica Hospital, Sesto San Giovanni, Italy.
³ Epidemiology and Preventive Pharmacology Service (SEFAP), Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
⁴ U. O. C. Clinica Medica 1, Department of Medicine-DIMED, University of Padua, Padua, Italy.
⁵ U. O. Medicina Interna Universitaria, Institute of Internal Medicine, University of Ferrara, Ferrara, Italy.
⁶ Department of Clinical and Experimental Medicine, Internal Medicine, University of Catania, Catania, Italy.
⁷ Unit of Internal and Metabolic Medicine, Civil Hospital of Baggiovara, A. O. U. of Modena and University of Modena and Reggio Emilia, Modena, Italy.
⁸ Research Laboratory of Lipid Metabolism Disorders and Atherosclerosis, Almazov National Medical Research Centre, St. Petersburg, Russian Federation.

PMID: 34875114
PMCID: PMC9300130
DOI: 10.1111/joim.13421

No abstract available

Keywords: achilles tendon xanthomata; familial hypercholesterolemia.

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Conflict of interest statement

The authors do not report any conflict of interest related to this work.

Figures

**Fig. 1**
Reclassification of Dutch Lipid Clinic Network (DLCN) categories by ultrasound‐based analysis of Achilles tendon xanthomata.

See this image and copyright information in PMC

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Li F, Ye P, Hao Y, Du J, Zhang H, Wang Z, Wang X, Zeng H, Ma Y, Lin J. Li F, et al. Atheroscler Plus. 2022 May 18;49:12-19. doi: 10.1016/j.athplu.2022.05.002. eCollection 2022 Aug. Atheroscler Plus. 2022. PMID: 36644203 Free PMC article.

References

1. Berberich AJ, Hegele RA. The complex molecular genetics of familial hypercholesterolaemia. Nat Rev Cardiol. 2019;16:9–20. - PubMed
1. Masana L, Zamora A, Plana N, Comas‐Cufí M, Garcia‐Gil M, Martí‐Lluch R, et al. Incidence of cardiovascular disease in patients with familial hypercholesterolemia phenotype: analysis of 5 years follow‐up of real‐world data from more than 1.5 million patients. J Clin Med. 2019;8:1080. - PMC - PubMed
1. McGowan MP, Hosseini Dehkordi SH, Moriarty PM, Duell PB. Diagnosis and treatment of heterozygous familial hypercholesterolemia. J Am Heart Assoc. 2019;8:e013225. - PMC - PubMed
1. Casula M, Olmastroni E, Pirillo A, Catapano AL, MEMBERS OF THE LIPIGEN STEERING COMMETTEE , PRINCIPAL INVESTIGATORS: Coordinator center , et al. Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study. Atherosclerosis. 2018;277:413–8. - PubMed
1. Junyent M, Gilabert R, Zambon D, Núñez I, Vela M, Civeira F, et al. The use of Achilles tendon sonography to distinguish familial hypercholesterolemia from other genetic dyslipidemias. Arterioscler Thromb Vasc Biol. 2005;25:2203–8. - PubMed

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Achilles tendon ultrasonography in familial hypercholesterolemia: A sub-study of the LIpid transPort disorders Italian GEnetic Network (LIPIGEN)

Affiliations

Achilles tendon ultrasonography in familial hypercholesterolemia: A sub-study of the LIpid transPort disorders Italian GEnetic Network (LIPIGEN)

Authors

Affiliations

Conflict of interest statement

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