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Comment
. 2021 Dec 6;56(23):3174-3176.
doi: 10.1016/j.devcel.2021.11.012.

Partial EMT takes the lead in cancer metastasis

Jef Haerinck  1 , Geert Berx  2
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Partial EMT takes the lead in cancer metastasis

Jef Haerinck et al. Dev Cell. .
Free article

Abstract

In this issue of Developmental Cell, Lüönd et al. developed a tracing system, using the uncharacterized early epithelial-mesenchymal transition (EMT)-marker Tenascin C, to monitor cells undergoing partial EMT during malignant mammary cancer progression. They find that partial, but not full, EMT contributes to metastasis and that full EMT contributes to chemoresistance.

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