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. 2021 Dec 7;21(1):1313.
doi: 10.1186/s12885-021-09037-3.

Degradation of skeletal mass in locally advanced oesophageal cancer between initial diagnosis and recurrence

Yacine Zouhry  1 , Abdelkader Taibi  2 , Sylvaine Durand-Fontanier  2 , Tiffany Darbas  1 , Geraud Forestier  3 , Jacques Monteil  4 , Valérie Lebrun-Ly  1 , Philippe Fayemendy  5   6 , Sophie Leobon  1 , Pierre Jesus  1 , Elise Deluche  7
Affiliations

Degradation of skeletal mass in locally advanced oesophageal cancer between initial diagnosis and recurrence

Yacine Zouhry et al. BMC Cancer. .

Abstract

Background: The prognostic value of a low skeletal mass index (SMI) has been investigated in locally advanced oesophageal (LAE) cancer at diagnosis. However, nothing is known about its evolution and clinical impact between initial diagnosis and recurrence.

Methods: A total of 89 patients treated for LAE cancer between January 2009 and December 2019 were included in this study. Computed tomography (CT) scans before treatment and at recurrence were evaluated. SMI and other body composition parameters were analysed by the L3 scan method.

Results: Participants were aged 66.0 (36.0-86) years. The incidence of low SMI increased by 12.3% between diagnosis and recurrence (70.7% vs. 83.0%, respectively) over a median follow-up of 16.9 (1.7-101.6) months. Patients with high SMI at diagnosis showed loss of muscle mass (58.0 vs. 55.2 cm2/m2, respectively; P < 0.001) and decreased body mass index (BMI) (27.9 vs. 26.3 kg/m2, respectively; P = 0.05), but fat mass was increased (68.9 vs. 72.0 cm2/m2, respectively; P = 0.01). Patients with low SMI at diagnosis showed no significant changes in body composition parameters and no improvement of SMI, even with nutritional support. Low SMI (hazard ratio [HR]: 1.8; 95% confidence interval [CI]: 1.02-3.16) was an independent predictor (P = 0.041) of high nutritional risk index (HR: 1.79; 95% CI: 1.03-3.11; P = 0.039) at diagnosis.

Conclusions: The percentage of patients with a low SMI increased during follow-up. Our data suggest that an assessment of skeletal muscle parameters and nutrition support may be more useful in patients with a high SMI.

Keywords: Nutrition; Oesophageal cancer; Outcome; Skeletal muscle mass.

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Conflict of interest statement

The authors declare that they have no conflicts of interest in relation to this study.

Figures

Fig. 1
Fig. 1
(a) Disease-free survival in the two skeletal muscle index groups. (b) Overall survival in the two skeletal muscle index groups Blue: high skeletal mass index (SMI); red: low skeletal mass index (SMI)
See this image and copyright information in PMC

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