Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Nov 5:19:1-3.
doi: 10.1016/j.jdcr.2021.10.031. eCollection 2022 Jan.

An adult with severe leukocyte adhesion deficiency type 1

Marija Geroldinger-Simić  1   2 , Konrad Lehner  1 , Georg Klein  1 , Norbert Sepp  1 , Jörg Jabkowski  1
Affiliations
Case Reports

An adult with severe leukocyte adhesion deficiency type 1

Marija Geroldinger-Simić et al. JAAD Case Rep. .
No abstract available

Keywords: HSCT, hematopoietic stem cell transplantation; IL, interleukin; ITGB2, integrin β2; LAD-1; LAD-1, leukocyte adhesion deficiency type 1; chronic wounds; leukocyte adhesion deficiency type 1; periodontitis.

PubMed Disclaimer

Conflict of interest statement

None disclosed.

Figures

Fig 1
Fig 1
Chronic wound on the right forearm of the 6-year-old patient.
Fig 2
Fig 2
Gingivitis in the 6-year-old patient.
Fig 3
Fig 3
Inflamed ulcer on the left shoulder of the 9-year-old patient.
See this image and copyright information in PMC

References

    1. Crowley C.A., Curnutte J.T., Rosin R.E., et al. An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. N Engl J Med. 1980;302(21):1163–1168. doi: 10.1056/NEJM198005223022102. - DOI - PubMed
    1. Hogg N., Stewart M.P., Scarth S.L., et al. A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1. J Clin Invest. 1999;103(1):97–106. doi: 10.1172/JCI3312. - DOI - PMC - PubMed
    1. Qasim W., Cavazzana-Calvo M., Davies E.G., et al. Allogeneic hematopoietic stem-cell transplantation for leukocyte adhesion deficiency. Pediatrics. 2009;123(3):836–840. doi: 10.1542/peds.2008-1191. - DOI - PMC - PubMed
    1. Almarza Novoa E., Kasbekar S., Thrasher A.J., et al. Leukocyte adhesion deficiency-I: a comprehensive review of all published cases. J Allergy Clin Immunol Pract. 2018;6(4):1418–1420.e10. doi: 10.1016/j.jaip.2017.12.008. - DOI - PubMed
    1. Bernard Cher T.H., Chan H.S., Klein G.F., et al. A novel 3′ splice-site mutation and a novel gross deletion in leukocyte adhesion deficiency (LAD)-1. Biochem Biophys Res Commun. 2011;404(4):1099–1104. doi: 10.1016/j.bbrc.2010.12.124. - DOI - PubMed

Publication types

LinkOut - more resources