Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2022 Dec;29(6):3086-3098.
doi: 10.1007/s12350-021-02864-8. Epub 2021 Dec 7.

Phase analysis for ventricular arrhythmia prediction: A retrospective monocentric cohort study

Maxime Beneyto  1   2 , Philippe Maury  3   4 , Anne Rollin  3 , Pierre Mondoly  3 , Franck Mandel  3 , Pierre Pascal  5 , Eve Cariou  6   7 , Didier Carrié  6 , Michel Galinier  6 , Olivier Lairez  6   7   5
Affiliations
Observational Study

Phase analysis for ventricular arrhythmia prediction: A retrospective monocentric cohort study

Maxime Beneyto et al. J Nucl Cardiol. 2022 Dec.

Abstract

Background: Prediction of ventricular arrhythmias (VA) mostly relies on left ventricular ejection fraction (LVEF), but with limited performance. New echocardiographic parameters such as mechanical dispersion have emerged, but acoustic window sometimes precludes this measurement. Nuclear imaging may be an alternative. We aimed to assess the ability of mechanical dispersion, measured with phase standard deviation (PSD) on radionuclide angiocardiography (RNA), to predict VAs.

Methods: This retrospective monocentric observational study included all patients who underwent a tomographic RNA from 2015 to 2019. Phase analysis yielded PSD and follow-up was examined to identify VAs, heart transplantation, and death.

Results: The study population consisted of 937 patients, mainly with LVEF ≤ 35% (425, 45%). Most had ischemic (334, 36%) or dilated cardiomyopathies (245, 26%). We identified 86 (9%) VAs. PSD was strongly associated with the occurrence of VA [hazard ratio per 10 ms increase (HR10) 1.12 (1.09-1.16)], heart transplantation [HR10 1.09 (1.06-1.12)], and death [HR10 1.03 (1.00-1.05)]. The association between PSD and VA persisted after adjustment for age, sex, QRS duration, LVEF, global longitudinal strain (GLS), and echocardiography-assessed mechanical dispersion.

Conclusion: The occurrence of ventricular arrhythmias was predicted by mechanical dispersion assessed by RNA, even after adjustment for LVEF and GLS.

Keywords: Mechanical dispersion; phase; radionuclide angiocardiography; sudden cardiac death; tomographic equilibrium blood-pool imaging; ventricular arrhythmia.

PubMed Disclaimer

Comment in

References

    1. Marwick TH. Ejection fraction pros and cons. J Am Coll Cardiol 2018;72:2360‐79. https://doi.org/10.1016/j.jacc.2018.08.2162 . - DOI
    1. Kawakami H, Nerlekar N, Haugaa KH, Edvardsen T, Marwick TH. Prediction of ventricular arrhythmias with left ventricular mechanical dispersion. JACC Cardiovasc Imaging 2019. https://doi.org/10.1016/j.jcmg.2019.03.025 . - DOI
    1. Haugaa KH, Grenne BL, Eek CH, Ersbøll M, Valeur N, Svendsen JH. Strain echocardiography improves risk prediction of ventricular arrhythmias after myocardial infarction. JACC Cardiovasc Imaging 2013;6:841‐50. https://doi.org/10.1016/j.jcmg.2013.03.005 . - DOI
    1. Haugaa KH, Smedsrud MK, Steen T, Kongsgaard E, Loennechen JP, Skjaerpe T, et al. Mechanical dispersion assessed by myocardial strain in patients after myocardial infarction for risk prediction of ventricular arrhythmia. JACC Cardiovasc Imaging 2010;3:247‐56. https://doi.org/10.1016/j.jcmg.2009.11.012 . - DOI
    1. Ersbøll M, Valeur N, Andersen MJ, Mogensen UM, Vinther M, Svendsen JH, et al. Early echocardiographic deformation analysis for the prediction of sudden cardiac death and life-threatening arrhythmias after myocardial infarction. JACC Cardiovasc Imaging 2013;6:851‐60. https://doi.org/10.1016/j.jcmg.2013.05.009 . - DOI

Publication types

LinkOut - more resources