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. 1986 Aug 1;233(4763):532-4.
doi: 10.1126/science.3487831.

Transforming growth factor-beta: biological function and chemical structure

M B Sporn, A B Roberts, L M Wakefield, R K Assoian

Transforming growth factor-beta: biological function and chemical structure

M B Sporn et al. Science. .

Abstract

Transforming growth factor-beta (TGF-beta) is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-beta and essentially all of them have specific receptors for this peptide. TGF-beta regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. Its marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications.

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