Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Dec 7;33(12):2305-2306.
doi: 10.1016/j.cmet.2021.11.009.

CoAching CD8+ T cells for tumor immunotherapy-the pantothenate way

Ameeta Kelekar  1 , Stephen C Jameson  2
Affiliations
Free article
Comment

CoAching CD8+ T cells for tumor immunotherapy-the pantothenate way

Ameeta Kelekar et al. Cell Metab. .
Free article

Abstract

The metabolic state of T cells strongly influences their effector function and anti-tumor efficacy. St. Paul et al. (2021) report that Tc22, a CD8+ T cell subset with potent anti-tumor activity, upregulates the pantothenate/coenzyme A (CoA) pathway and that treatment with CoA or pantothenate is sufficient to enhance tumor immunotherapy.

PubMed Disclaimer

Comment on

  • Coenzyme A fuels T cell anti-tumor immunity.
    St Paul M, Saibil SD, Han S, Israni-Winger K, Lien SC, Laister RC, Sayad A, Penny S, Amaria RN, Haydu LE, Garcia-Batres CR, Kates M, Mulder DT, Robert-Tissot C, Gold MJ, Tran CW, Elford AR, Nguyen LT, Pugh TJ, Pinto DM, Wargo JA, Ohashi PS. St Paul M, et al. Cell Metab. 2021 Dec 7;33(12):2415-2427.e6. doi: 10.1016/j.cmet.2021.11.010. Cell Metab. 2021. PMID: 34879240

LinkOut - more resources