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Comment
. 2021 Dec 7;33(12):2309-2311.
doi: 10.1016/j.cmet.2021.11.006.

Estrogen wars: The activity awakens

Miguel López  1
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Estrogen wars: The activity awakens

Miguel López. Cell Metab. .
Free article

Abstract

The mechanisms by which estrogens modulate physical activity remain unclear. A recent article published in Nature by Krause et al. (2021) demonstrates that estradiol increases the expression of melanocortin receptor 4 in a particular subset of neurons in the ventromedial nucleus of the hypothalamus, leading to increased physical activity.

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