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Meta-Analysis
. 2022 Feb;102(2):115589.
doi: 10.1016/j.diagmicrobio.2021.115589. Epub 2021 Oct 30.

The potential of volatile organic compounds-based breath analysis for COVID-19 screening: a systematic review & meta-analysis

Anita Dominique Subali  1 , Lowilius Wiyono  2 , Muhammad Yusuf  3 , Muhammad Fathi Athallah Zaky  3
Affiliations
Meta-Analysis

The potential of volatile organic compounds-based breath analysis for COVID-19 screening: a systematic review & meta-analysis

Anita Dominique Subali et al. Diagn Microbiol Infect Dis. 2022 Feb.

Abstract

COVID-19 is a major problem with an increasing incidence and mortality. The discovery of Volatile Organic Compounds (VOCs) based on breath analysis offers a reliable, rapid, and affordable screening method. This study examined VOC-based breath analysis diagnostic performance for SARS-COV-2 infection compared to RT-PCR. A systematic review was conducted in 8 scientific databases based on the PRISMA guideline. Original English studies evaluating human breaths for COVID-19 screening and mentioning sensitivity and specificity value compared to RT-PCR were included. Six studies were included with a total of 4093 samples from various settings. VOCs-based breath analysis had the cumulative sensitivity of 98.2% (97.5% CI 93.1%-99.6%) and specificity of 74.3% (97.5% CI 66.4%-80.9%). Subgroup analysis on chemical analysis (GC-MS) and pattern recognition (eNose) revealed higher sensitivity in the eNose group. VOC-based breath analysis shows high sensitivity and promising specificity for COVID-19 public screening.

Keywords: COVID-19, screening, diagnosis, volatile organic compound; breath analysis, breath-testing.

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Figures

Fig 1
Fig. 1
Literature search flowchart.
Fig 2
Fig. 2
QUADAS-2 assessment on the risk of bias and concerns of applicability.
Fig 3
Fig. 3
Forest plot of sensitivity and specificity of VOC-based breath analysis on included studies.
See this image and copyright information in PMC

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References

    1. Long C, Xu H, Shen Q, Zhang X, Fan B, Wang C, et al. Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT? Eur J Radiol. 2020;126 doi: 10.1016/j.ejrad.2020.108961. - DOI - PMC - PubMed
    1. McArthur L, Sakthivel D, Ataide R, Chan F, Richards JS, Narh CA. Review of burden, clinical definitions, and management of Covid-19 Cases. Am J Trop Med Hyg. 2020;103(2):625–638. doi: 10.4269/ajtmh.20-0564. - DOI - PMC - PubMed
    1. WHO. Advice for the public. 2020. Available at: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-f.... Accessed June 16, 2021.
    1. WHO. WHO coronavirus (COVID-19) dashboard | WHO coronavirus (COVID-19) dashboard with vaccination data. 2021. Available at: https://covid19.who.int/. Accessed September 26, 2021.
    1. Berna AZ, Akaho EH, Harris RM, Congdon M, Korn E. Reproducible breath metabolite changes in children with SARS-CoV-2 infection. ACS Infect Dis. 2021;7(9):2596–2603. doi: 10.1021/acsinfecdis.1c00248. - DOI - PMC - PubMed

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