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. 2022 Mar;196(5):1257-1261.
doi: 10.1111/bjh.17988. Epub 2021 Dec 8.

The incidence of symptomatic osteonecrosis is similar between Japanese children and children in Western countries with acute lymphoblastic leukaemia treated with a Berlin-Frankfurt-Münster (BFM)95-based protocol

Kunihiko Moriya  1 , Toshihiko Imamura  2 , Saori Katayama  1 , Akira Kaino  1 , Kenji Okamoto  2 , Norihumi Yokoyama  3 , Suguru Uemura  4 , Hironobu Kitazawa  5 , Masahiro Sekimizu  6 , Hidefumi Hiramatsu  7 , Ikuya Usami  8 , Hisashi Ishida  9   10 , Daiichiro Hasegawa  4 , Asahito Hama  5 , Akiko Moriya-Saito  10 , Atsushi Sato  11 , Yoji Sasahara  1 , Souichi Suenobu  12 , Keizo Horibe  6 , Junichi Hara  13 ; Japan Association of Childhood Leukemia Study Group (JACLS)
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The incidence of symptomatic osteonecrosis is similar between Japanese children and children in Western countries with acute lymphoblastic leukaemia treated with a Berlin-Frankfurt-Münster (BFM)95-based protocol

Kunihiko Moriya et al. Br J Haematol. 2022 Mar.

Abstract

In this study, we performed a retrospective analysis of a cohort of Japanese paediatric patients with B-cell precursor (BCP)-acute lymphoblastic leukaemia (ALL) treated with a Berlin-Frankfurt-Münster (BFM)95-based protocol, to clarify the incidence, clinical characteristics, and risk factors of osteonecrosis (ON) in comparison to the ALL-02 protocol. We identified a high frequency of ON with the BFM95-based protocol compared to the ALL-02 protocol. The incidence of symptomatic ON with the BFM95-based protocol is comparable to previous studies in Western countries. We believe that the type of treatment regimen has more impact on the incidence of symptomatic ON in paediatric ALL than ethnicity.

Keywords: Berlin-Frankfurt-Münster (BFM)95-based protocol; Japanese children; acute lymphoblastic leukaemia; osteonecrosis.

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References

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