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. 2022 Dec;35(25):9066-9070.
doi: 10.1080/14767058.2021.2014450. Epub 2021 Dec 8.

Association between diagnosed perinatal mood and anxiety disorders and adverse perinatal outcomes

Eynav Accortt  1 , James Mirocha  2 , Susan Jackman  1 , Mary Coussons-Read  3 , Christine Dunkel Schetter  4 , Calvin Hobel  1
Affiliations

Association between diagnosed perinatal mood and anxiety disorders and adverse perinatal outcomes

Eynav Accortt et al. J Matern Fetal Neonatal Med. 2022 Dec.

Abstract

Purpose: To determine whether a diagnosis of a perinatal mood and anxiety disorder (PMAD) is associated with adverse perinatal outcomes.

Methods: Mental health symptom screening and diagnostic data from 82 women with single gestation in the Healthy Babies Before Birth study conducted from 2013 to 2018 were obtained by clinic interview. If a woman scored over 10 on the Patient Health Questionnaire (PHQ-9) or endorsed the suicidality item; or scored over 7 on the Overall Anxiety Severity and Impairment Scale (OASIS), a Structured Clinical Interview for DSM-IV (SCID) Axis I Disorders was administered. An adverse perinatal outcome was operationalized as a diagnosis of gestational diabetes mellitus, intrauterine growth restriction, preeclampsia, chorioamnionitis, hemorrhage, fetal death, preterm birth, or a low birthweight baby, and abstracted from the medical records.

Results: Women were between 22.0 and 45.0 years old (Mean age = 33.1 ± 4.3). Mean BMI was 24.7 ± 5.6 (Range 16.8 to 47.1). Nineteen percent (16) of the 82 women had a SCID diagnosis of a PMAD. Thirty-seven percent (30) had a diagnosed adverse perinatal outcome. Multiple logistic regression was conducted with these predictors: SCID diagnosis of a PMAD, maternal age, BMI. All predictors were significant with respective odds ratios as follows: OR = 3.58, 95% CI 1.03-12.44, p = .045; OR = 2.30, 95% CI 1.21-4.38, p = .011; OR = 1.69, 95% CI 1.06-2.69, p = .027.

Conclusions: A PMAD diagnosis was associated with 3.5 times higher odds of having an adverse perinatal outcome. For every 5 years a woman aged or every five units her BMI increased her odds of having an adverse perinatal outcome increased. Older age and increased BMI are well established adverse perinatal outcome risk factors. These results suggest that mental illness risk should also be consistently assessed in obstetric settings.

Keywords: Perinatal mood and anxiety disorders; adverse perinatal outcomes; postpartum depression; prenatal depression.

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Conflict of interest statement

Disclosure statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Study timeline.
See this image and copyright information in PMC

References

    1. Accortt EE, Wong MS. It is time for routine screening for perinatal mood and anxiety disorders in obstetrics and gynecology settings. Obstet Gynecol Surv. 2017;72(9):553–568. - PubMed
    1. Reck C, Struben K, Backenstrass M, et al. Prevalence, onset and comorbidity of postpartum anxiety and depressive disorders. Acta Psychiatr Scand. 2008;118(6):459–468. - PubMed
    1. Gjerdingen D, Yawn B. Postpartum depression screening: Importance, methods, barriers, and recommendations for practice. J Am Board Fam Med. 2007;20(3):280–2881. - PubMed
    1. Zuckerman B, Amaro H, Bauchner H, et al. Depressive symptoms during pregnancy: relationship to poor health behaviors. Am J Obstet Gynecol. 1989;160(5 Pt 1):1107–1111. - PubMed
    1. Burt VK, Stein K. Epidemiology of depression throughout the female life cycle. J Clin Psychiatry. 2002;63(Suppl 7):9–15. - PubMed