Truly Man's Best Friend: Canine Cancers Drive Drug Repurposing in Osteosarcoma
- PMID: 34880110
- DOI: 10.1158/1078-0432.CCR-21-3471
Truly Man's Best Friend: Canine Cancers Drive Drug Repurposing in Osteosarcoma
Abstract
While metastatic osteosarcoma is rare in humans, it is the most common bone tumor found in any breed of dog. Given the genetic similarities between canine and human osteosarcomas, canine clinical trials allow for rapid testing and drug repurposing at a speed that cannot be achieved using patients with osteosarcoma. See related article by Regan et al., p. 662.
©2021 American Association for Cancer Research.
Comment on
-
Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma.Clin Cancer Res. 2022 Feb 15;28(4):662-676. doi: 10.1158/1078-0432.CCR-21-2105. Clin Cancer Res. 2022. PMID: 34580111 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
