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Review
. 2021 Dec 31;56(4):215-228.
doi: 10.5045/br.2021.2021094.

Effects and treatment applications of polymeric nanoparticles on improving platelets' storage time: a review of the literature from 2010 to 2020

Tahereh Zadeh Mehrizi  1 , Sedigheh Amini Kafiabad  1 , Peyman Eshghi  2
Affiliations
Review

Effects and treatment applications of polymeric nanoparticles on improving platelets' storage time: a review of the literature from 2010 to 2020

Tahereh Zadeh Mehrizi et al. Blood Res. .

Abstract

Maintaining the quality of platelet products and increasing their storage time are priorities for treatment applications. The formation of platelet storage lesions that limit the storage period and preservation temperature, which can prepare a decent environment for bacterial growth, are the most important challenges that researchers are dealing with in platelet preservation. Nanotechnology is an emerging field of science that has introduced novel solutions to resolve these problems. Here, we reviewed the reported effects of polymeric nanoparticles-including chitosan, dendrimers, polyethylene glycol (PEG), and liposome-on platelets in articles from 2010 to 2020. As a result, we concluded that the presence of dendrimer nanoparticles with a smaller size, negative charge, low molecular weight, and low concentration along with PEGylation can increase the stability and survival of platelets during storage. In addition, PEGylation of platelets can also be a promising approach to improve the quality of platelet bags during storage.

Keywords: Chitosan; Dendrimer; PEGylation; Platelet storage lesion; Platelet storage time.

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Conflict of interest statement

Authors’ Disclosures of Potential Conflicts of Interest

No potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1
Molecular structure of a platelet.
Fig. 2
Fig. 2
Chemical structure of chitosan.
Fig. 3
Fig. 3
Chemical structure of PLGA.
Fig. 4
Fig. 4
Chemical structure of a PAMAM dendrimer.
Fig. 5
Fig. 5
Chemical structure of PEG.
See this image and copyright information in PMC

References

    1. Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA. Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med. 2009;37:2259–72. doi: 10.1177/0363546509349921. - DOI - PubMed
    1. Árnason NA, Sigurjónsson OE. New strategies to understand platelet storage lesion. ISBT Sci Ser. 2017;12:496–500. doi: 10.1111/voxs.12394. - DOI
    1. Stohlawetz P, Horvath M, Pernerstorfer T, et al. Effects of nitric oxide on platelet activation during plateletpheresis and in vivo tracking of biotinylated platelets in humans. Transfusion. 1999;39:506–14. doi: 10.1046/j.1537-2995.1999.39050506.x. - DOI - PubMed
    1. Shrivastava M. The platelet storage lesion. Transfus Apher Sci. 2009;41:105–13. doi: 10.1016/j.transci.2009.07.002. - DOI - PubMed
    1. Verma A, Agarwal P. Platelet utilization in the developing world: strategies to optimize platelet transfusion practices. Transfus Apher Sci. 2009;41:145–9. doi: 10.1016/j.transci.2009.07.005. - DOI - PubMed