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. 2021 Dec 8;11(1):23677.
doi: 10.1038/s41598-021-03139-5.

Survival impact of treatment for chronic obstructive pulmonary disease in patients with advanced non-small-cell lung cancer

Hitomi Ajimizu  1 , Hiroaki Ozasa  1 , Susumu Sato  2 , Tomoko Funazo  1 , Yuichi Sakamori  1 , Takashi Nomizo  1 , Kiyomitsu Kuninaga  1 , Tatsuya Ogimoto  1 , Kazutaka Hosoya  1 , Masatoshi Yamazoe  1 , Takahiro Tsuji  1 , Hironori Yoshida  1 , Ryo Itotani  1 , Kentaro Ueno  3 , Young Hak Kim  1 , Shigeo Muro  4 , Toyohiro Hirai  1
Affiliations

Survival impact of treatment for chronic obstructive pulmonary disease in patients with advanced non-small-cell lung cancer

Hitomi Ajimizu et al. Sci Rep. .

Erratum in

Abstract

Chronic obstructive pulmonary disease (COPD) may coexist with lung cancer, but the impact on prognosis is uncertain. Moreover, it is unclear whether pharmacological treatment for COPD improves the patient's prognosis. We retrospectively investigated patients with advanced non-small-cell lung cancer (NSCLC) who had received chemotherapy at Kyoto University Hospital. Coexisting COPD was diagnosed by spirometry, and the association between pharmacological treatment for COPD and overall survival (OS) was assessed. Of the 550 patients who underwent chemotherapy for advanced NSCLC between 2007 and 2014, 347 patients who underwent spirometry were analyzed. Coexisting COPD was revealed in 103 patients (COPD group). The median OS was shorter in the COPD group than the non-COPD group (10.6 vs. 16.8 months). Thirty-seven patients had received COPD treatment, and they had a significantly longer median OS than those without treatment (16.7 vs. 8.2 months). Multivariate Cox regression analysis confirmed the positive prognostic impact of COPD treatment. Additional validation analysis revealed similar results in patients treated with immune checkpoint inhibitors (ICIs). Coexisting COPD had a significant association with poor prognosis in advanced NSCLC patients if they did not have pharmacological treatment for COPD. Treatment for coexisting COPD has the potential to salvage the prognosis.

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Conflict of interest statement

This study was supported by a grant from Nippon Boehringer Ingelheim (BI). SS received this grant from BI. BI had no role in the design, analysis or interpretation of the study or in the writing of the manuscript. BI was given the opportunity to review the manuscript for medical and scientific accuracy as it relates to BI substances, as well as intellectual property considerations. All other authors have no competing interests.

Figures

Figure 1
Figure 1
Kaplan–Meier curve of OS stratified by COPD. Coexisting COPD was associated with a significantly shorter OS in advanced NSCLC patients (P = 0.0002*, log-rank test). CI confidence interval, HR hazard ratio.
Figure 2
Figure 2
Kaplan–Meier curve of OS stratified by COPD treatment. COPD treatment was associated with a significantly longer OS in advanced NSCLC patients (P = 0.023*, log-rank test). CI confidence interval, HR hazard ratio.
See this image and copyright information in PMC

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