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Review
. 2021 Nov 24;19(4):15593258211056199.
doi: 10.1177/15593258211056199. eCollection 2021 Oct-Dec.

A Systematic Review on the Role of the Perfusion Computed Tomography in Abdominal Cancer

Nunzia Garbino  1 , Valentina Brancato  1 , Marco Salvatore  1 , Carlo Cavaliere  1
Affiliations
Review

A Systematic Review on the Role of the Perfusion Computed Tomography in Abdominal Cancer

Nunzia Garbino et al. Dose Response. .

Abstract

Background and purpose: Perfusion Computed Tomography (CTp) is an imaging technique which allows quantitative and qualitative evaluation of tissue perfusion through dynamic CT acquisitions. Since CTp is still considered a research tool in the field of abdominal imaging, the aim of this work is to provide a systematic summary of the current literature on CTp in the abdominal region to clarify the role of this technique for abdominal cancer applications.

Materials and methods: A systematic literature search of PubMed, Web of Science, and Scopus was performed to identify original articles involving the use of CTp for clinical applications in abdominal cancer since 2011. Studies were included if they reported original data on CTp and investigated the clinical applications of CTp in abdominal cancer.

Results: Fifty-seven studies were finally included in the study. Most of the included articles (33/57) dealt with CTp at the level of the liver, while a low number of studies investigated CTp for oncologic diseases involving UGI tract (8/57), pancreas (8/57), kidneys (3/57), and colon-rectum (5/57).

Conclusions: Our study revealed that CTp could be a valuable functional imaging tool in the field of abdominal oncology, particularly as a biomarker for monitoring the response to anti-tumoral treatment.

Keywords: abdominal cancer; abdominal imaging; computed tomography perfusion; perfusion parameter.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Preferred reporting items for systematic reviews and meta-analyses (PRISMA) flow diagram.
Figure 2.
Figure 2.
Graphic summary of the systematic review results according to the abdominal zone and clinical purposes investigated in the selected studies. The donut chart shows the number of included studies according to the abdominal zone investigated (liver in orange; upper gastrointestinal tract in yellow; pancreas in green; kidneys in blue; colon/rectum in red). Number and percentage of studies included in each of the five groups were reported investigates. For each group, the bar plots show the number of studies according to the clinical purpose investigated. Abbreviations: UGI = Upper Gastrointestinal.
Figure 3.
Figure 3.
Quality assessment using QUADAS-2 tool for diagnostic studies.
Figure 4.
Figure 4.
Quality assessment using QUIPS tool for prognostic studies.
See this image and copyright information in PMC

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