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. 2021 Nov 22:12:759221.
doi: 10.3389/fneur.2021.759221. eCollection 2021.

Trends in Incidence and Mortality of Stroke in China From 1990 to 2019

Tong Sun  1 , Siyang Chen  2 , Ke Wu  3 , Min Sun  2 , Xianyan Zhang  2 , Chao You  1
Affiliations

Trends in Incidence and Mortality of Stroke in China From 1990 to 2019

Tong Sun et al. Front Neurol. .

Abstract

Objective: Stroke is a leading cause of mortality and morbidity globally. This study aimed to analyze the burden and 30-year trends of ischemic stroke, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH) in China. Methods: Data that include incidence and mortality of stroke in China from January 1, 1990 to December 31, 2019 were derived from the Global Burden of Disease (GBD) study 2019. The absolute numbers of incident cases and deaths over the time, and age-standardized rates per 100,000, such as age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR), were analyzed. Results: In 2019, there were 3.9 (95% uncertainty intervals (UI) 3.4-4.5) million incident cases and 2.1 (3.4-4.5) million deaths related to stroke in China. The ASIR and ASMR of stroke in China was 200 (176-230) and 127 (110-144). From 1990 to 2019, the ASIR of ischemic stroke had increased by 35.0% (29.0-40.0) while the ASIR of ICH and SAH had decreased by -53.0% (-56.0 to -50.0) and by -39.0% (-44.0 to -35.0), respectively. The ASMR of ischemic stroke had increased by 3.0% (-26.0 to 16.0) while the ASMR of ICH and SAH had decreased by -48.0% (-59.0 to -38.0) and by -84.0% (-89.0 to -69.0), respectively. Conclusion: Although the incidence and mortality rates of stroke in China were decreased from 1990 to 2019, the number of incident cases and deaths nearly doubled. A sharp increase in the incidence rate of ischemic stroke was observed. A higher incidence rate of ischemic stroke in the women was also observed.

Keywords: burden; incidence; mortality; stroke; trends.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The trends in incidence of strokes. (A) Number of the incident cases with uncertainty from 1990 to 2019 in China. (B) Age-standardized incidence rate per 100,000 with uncertainty from 1990 to 2019 in China. (C) The age-standardized incidence rates per 100,000 of different age groups. ASIR, age-standardized incidence rate; ICH, intracerebral hemorrhage; and SAH, subarachnoid hemorrhage. The figures were generated through GBD Results Tool and GBD Compare Tool.
Figure 2
Figure 2
(A) Comparison of men and women in the age-standardized incidence rate per 100,000 of ischemic stroke. (B) Comparison of men and women in the age-standardized incidence rate per 100,000 of intracerebral hemorrhage. (C) Comparison of men and women in the age-standardized incidence rate per 100,000 of subarachnoid hemorrhage. ASIR, age-standardized incidence rate; ICH, intracerebral hemorrhage; and SAH, subarachnoid hemorrhage. The figures were generated through GBD Results Tool.
Figure 3
Figure 3
The trends in mortality of strokes. (A) Number of deaths with uncertainty from 1990 to 2019 in China. (B) Age-standardized mortality rate per 100,000 with uncertainty from 1990 to 2019 in China. (C) The age-standardized mortality rates per 100,000 of different age groups. ASMR, age-standardized mortality rate ICH, intracerebral hemorrhage; and SAH, subarachnoid hemorrhage. The figures were generated through GBD Results Tool and GBD Compare Tool.
Figure 4
Figure 4
(A) Comparison of men and women in the age-standardized mortality rate per 100,000 of ischemic stroke. (B) Comparison of men and women in the age-standardized mortality rate per 100,000 of intracerebral hemorrhage. (C) Comparison of men and women in the age-standardized mortality rate per 100,000 of subarachnoid hemorrhage. ASMR, age-standardized mortality rate; ICH, intracerebral hemorrhage; and SAH, subarachnoid hemorrhage. The figures were generated through GBD Results Tool.
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