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Review
. 2021 Nov 22:11:757718.
doi: 10.3389/fcimb.2021.757718. eCollection 2021.

Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species

Kai Nie  1   2 , Kejia Ma  1   2 , Weiwei Luo  1   2 , Zhaohua Shen  1   2 , Zhenyu Yang  1   2 , Mengwei Xiao  1   2 , Ting Tong  1   2 , Yuanyuan Yang  1   2 , Xiaoyan Wang  1   2
Affiliations
Review

Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species

Kai Nie et al. Front Cell Infect Microbiol. .

Abstract

Roseburia intestinalis is an anaerobic, Gram-positive, slightly curved rod-shaped flagellated bacterium that produces butyrate in the colon. R. intestinalis has been shown to prevent intestinal inflammation and maintain energy homeostasis by producing metabolites. Evidence shows that this bacterium contributes to various diseases, such as inflammatory bowel disease, type 2 diabetes mellitus, antiphospholipid syndrome, and atherosclerosis. This review reveals the potential therapeutic role of R. intestinalis in human diseases. Patients with inflammatory bowel disease exhibit significant changes in R. intestinalis abundance, and they may benefit a lot from modulations targeting R. intestinalis. The data reviewed here demonstrate that R. intestinalis plays its role in regulating barrier homeostasis, immune cells, and cytokine release through its metabolite butyrate, flagellin and other. Recent advancements in the application of primary culture technology, culture omics, single-cell sequencing, and metabonomics technology have improved research on Roseburia and revealed the benefits of this bacterium in human health and disease treatment.

Keywords: Roseburia; Roseburia intestinalis; inflammatory bowel disease (IBD); microbiome; probiotic.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Roseburia intestinalis modulation in the colonic tract. The butyrate produced by R. intestinalis exerts an extensive effect on energy metabolism, gut barrier, and anti-inflammation. R. intestinalis stimulates enteric cells, thereby excreting cytokines, promoting the differentiation of regulatory T cells (Tregs), and activating type 3 innate lymphoid cells (ILC3). It also suppresses Th17 and macrophages. Its flagellin displays an anti-inflammation effect through TLR5. The biological effect induced by R. intestinalis exhibits a significant probiotic-like role. R. intestinalis also influences the energy metabolism and the gut–brain axis. A plus sign indicates promote and a minus sign indicates inhibit. GPCRs, G-protein coupled receptors; TSLP, thymic stromal lymphopoietin; GLP-1, glucagon-like peptide-1; PYY, peptide YY; OSM, oncostatin M; hREG3α, human regenerating family member 3 alpha; TLR5, Toll-like receptor 5; IDO1, indoleamine 2,3-dioxygenase-1; HIF1A-AS2, lncRNA (HIF1A-AS2).
Figure 2
Figure 2
Roseburia dysbiosis-associated diseases exist in different systems. IBD, inflammatory bowel diseases; IBS, irritable bowel syndrome; NAFLD, non-alcoholic fatty liver disease; AFLD, alcoholic fatty liver disease; CRD, chronic rheumatoid disease; APS, antiphospholipid syndrome; HIV, human immunodeficiency virus; H7N9, avian influenza A (H7N9); ARDS, acute respiratory distress syndrome.
Figure 3
Figure 3
Different therapeutic methods targeting Roseburia intestinalis in potential diseases. IBD, inflammatory bowel disease; MDD, major depressive disorder; PD, Parkinson’s disease; AFLD, alcoholic fatty liver disease.
See this image and copyright information in PMC

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