An Arab Adolescent with Multisystem Inflammatory Syndrome Associated with COVID-19: A Report from Syria
- PMID: 34881206
- PMCID: PMC8648403
- DOI: 10.1055/s-0041-1734387
An Arab Adolescent with Multisystem Inflammatory Syndrome Associated with COVID-19: A Report from Syria
Abstract
Multisystem inflammatory syndrome in children (MIS-C) is a rare and critical condition that affects children following exposure to severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, leading to multiorgan dysfunction and shock. MIS-C has been reported from different parts of the world but rarely from Arab countries. In this report, we describe a 15-year-old Arab boy who was admitted to the ICU during the surge of Coronavirus transmission in Syria with a clinical picture consistent with MIS-C, including high-grade fever, gastrointestinal symptoms, rash, multiorgan dysfunction, and shock. Laboratory profile showed significant elevation of inflammatory markers, negative SARS-CoV-2 RT-PCR testing but positive serologic testing for SARS-CoV-2. The patient received intravenous immunoglobulins (IVIG) and glucocorticoids with remarkable cardiac improvement and significant alleviation in inflammatory markers. To our knowledge, this is the first reported case of MIS-C from Syria, which adds to the epidemiological data about this new syndrome.
Keywords: arab; coronavirus disease 2019 (COVID-19); kawasaki disease; multisystem inflammatory syndrome in children (MIS-C); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Conflict of interest statement
Conflict of Interest None declared.
Similar articles
-
Multisystem inflammatory syndrome in children during the coronavirus disease 2019 (COVID-19) pandemic: a systematic review of published case studies.Transl Pediatr. 2021 Jan;10(1):121-135. doi: 10.21037/tp-20-188. Transl Pediatr. 2021. PMID: 33633944 Free PMC article.
-
A 7-Year-Old Boy and a 14-Year-Old Girl Initially Diagnosed with Toxic Shock Syndrome and Tested Positive for SARS-CoV-2 Infection, Supporting a Diagnosis of Multisystem Inflammatory Syndrome in Children (MIS-C).Am J Case Rep. 2021 Oct 12;22:e931570. doi: 10.12659/AJCR.931570. Am J Case Rep. 2021. PMID: 34635631 Free PMC article.
-
COVID-19: Multisystem Inflammatory Syndrome in Children (MIS-C).Cureus. 2022 Jan 9;14(1):e21064. doi: 10.7759/cureus.21064. eCollection 2022 Jan. Cureus. 2022. PMID: 35165539 Free PMC article.
-
Human and novel coronavirus infections in children: a review.Paediatr Int Child Health. 2021 Feb;41(1):36-55. doi: 10.1080/20469047.2020.1781356. Epub 2020 Jun 25. Paediatr Int Child Health. 2021. PMID: 32584199 Review.
-
Mechanisms of Immune Dysregulation in COVID-19 Are Different From SARS and MERS: A Perspective in Context of Kawasaki Disease and MIS-C.Front Pediatr. 2022 May 5;10:790273. doi: 10.3389/fped.2022.790273. eCollection 2022. Front Pediatr. 2022. PMID: 35601440 Free PMC article. Review.
References
-
- Dong Y, Mo X, Hu Y. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145(06):e20200702. - PubMed
-
- Centers for Disease Control and Prevention. Multisystem inflammatory syndrome in children (MIS-C) associated with Coronavirus disease. Available at: https://emergency.cdc.gov/han/2020/han00432.asp. Accessed September 23, 2020.
-
- American Academy of Pediatrics clinical guidance: multisystem inflammatory syndrome in children (MIS-C). Available at: https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infect.... Accessed June 9, 2021
Publication types
LinkOut - more resources
Full Text Sources
Miscellaneous