Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Jun;5(6):1245-52.
doi: 10.1002/j.1460-2075.1986.tb04353.x.

T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells

A Tunnacliffe, J E Sims, T H Rabbitts

T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells

A Tunnacliffe et al. EMBO J. 1986 Jun.

Abstract

The human T-cell antigen receptor-associated T3 complex consists of at least three polypeptides, gamma, delta and epsilon. cDNA clones for the delta-chain have recently been obtained and we have used such clones to isolate the T3 delta gene. The gene has been sequenced and comprises five exons, spread over approximately 3.7 kb of DNA. Transcription of the T3 delta gene is initiated from a non-TATA promoter. S1 mapping experiments and the sequence of a novel cDNA clone show that T3 delta mRNA exists in two forms in T cells. Alternative splicing of pre-mRNA sequences corresponding to the third exon of the T3 delta gene accounts for the two species of mRNA. A putative protein, produced by translation of the shorter mRNA, would lack a transmembrane region and might be secreted or associated with the outer surface of the cell.

PubMed Disclaimer

References

    1. EMBO J. 1983;2(8):1373-8 - PubMed
    1. EMBO J. 1985 Feb;4(2):437-43 - PubMed
    1. Nature. 1979 Dec 13;282(5740):680-6 - PubMed
    1. Nature. 1980 Feb 21;283(5749):743-5 - PubMed
    1. J Immunol. 1980 Jun;124(6):2708-13 - PubMed

Publication types

Associated data