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. 2021 Dec 10;374(6573):1325-1326.
doi: 10.1126/science.abk3436. Epub 2021 Dec 9.

Oncolytic virotherapy as immunotherapy

Alan Melcher  1 , Kevin Harrington  1 , Richard Vile  2
Affiliations

Oncolytic virotherapy as immunotherapy

Alan Melcher et al. Science. .

Abstract

Recognizing immune responses to oncolytic virotherapy opens the way for new combinations.

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Figures

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Oncolytic viruses are multifaceted tumor killers
Oncolytic viruses delivered to the tumor not only kill tumor cells directly, but also potentiate antitumor immune responses by releasing antigens and activating inflammatory responses. This may allow immunologically “cold” tumors to become “hot.”
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References

    1. Filley AC, Dey M, Front. Oncol 7, 106 (2017). - PMC - PubMed
    1. Dunn GP et al., Annu. Rev. Immunol 22, 329 (2004). - PubMed
    1. Garcia-Carbonero R et al., J. Immunother. Cancer 5, 71 (2017). - PMC - PubMed
    1. Breitbach CJ et al., Nature 477, 99 (2011). - PubMed
    1. Samson A et al., Sci. Transl. Med 10, 422 (2018). - PMC - PubMed

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